复方乙酰水杨酸片中有效成分的DOSY技术分析
收稿日期: 2015-10-08
修回日期: 2016-07-10
网络出版日期: 2016-09-05
基金资助
国家自然科学基金资助项目（21105108）.
Quantitative Analysis of Active Ingredients in Compound Acetylsalicylic Acid Tablets by DOSY
Received date: 2015-10-08
Revised date: 2016-07-10
Online published: 2016-09-05
复方乙酰水杨酸片是临床常用的解热镇痛消炎药物，目前其有效成分的分析方法存在操作繁琐而分析速度慢等不足. 该文利用二甲基硅油（PDMS）辅助的扩散排序（DOSY）技术以及扩散排序-同核相关（DOSY-COSY）联用技术，成功地对复方乙酰水杨酸片中三种有效成分的分子结构进行了快速定性分析，并且利用核磁共振氢谱（1H NMR）技术进行了相对定量分析. 该方法具有方便、快捷等特点，可作为借鉴和参考用于药物的质量评价.
关键词： 复方乙酰水杨酸片; 药物评价; 核磁共振(NMR); 二维扩散排序谱(DOSY); 二甲基硅油(PDMS)
王丽敏 , 仇汝臣 , 黄少华 . 复方乙酰水杨酸片中有效成分的DOSY技术分析[J]. 波谱学杂志, 2016 , 33(3) : 415 -421 . DOI: 10.11938/cjmr20160306
Compound acetylsalicylic acid tablet is a clinical drug having antipyretic, analgesic and anti-inflammatory effects. The present methods to analyze the active ingredients in this drug have many disadvantages. In this study, we used polydimethylsiloxane (PDMS)-assisted diffusion ordered NMR spectroscopy (DOSY), DOSY-correlated spectroscopy (COSY), and relative quantitative 1H NMR techniques to analyze the three main active ingredients in this drug. The content ratios among the 3 components could be obtained. It is argued that PDMS-assisted DOSY provides a convenient and efficient method for pharmaceutical quality control of compound acetylsalicylic acid tablets.
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