组织凝固性坏死对基于纵向弛豫时间的磁共振测温的影响

洪声秀; 胡红兵; 杨增涛; 张天峰; 黄磊; 王华

doi:10.11938/cjmr20182624

波谱学杂志 >

2018 , Vol. 35 >Issue 4: 440 - 446

DOI: https://doi.org/10.11938/cjmr20182624

研究论文

组织凝固性坏死对基于纵向弛豫时间的磁共振测温的影响

洪声秀 ,
胡红兵 ,
杨增涛 ,
张天峰 ,
黄磊 ,
王华

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1. 重庆医科大学生物医学工程学院, 省部共建国家重点实验室培育基地-重庆市超声医学工程重点实验室, 重庆市生物医学工程学重点实验室重庆市微无创医学协同创新中心, 重庆 400016;
2. 超声医疗国家工程研究中心, 重庆 401121

收稿日期: 2018-03-21

网络出版日期: 2018-07-16

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Effects of Tissue Coagulative Necrosis on Longitudinal Relaxation Time-Based Magnetic Resonance Thermometry

HONG Sheng-xiu ,
HU Hong-bing ,
YANG Zeng-tao ,
ZHANG Tian-feng ,
HUANG Lei ,
WANG Hua

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1. State Key Laboratory of Ultrasound Engineering in Medicine Co-Founded by Chongqing and the Ministry of Science and Technology, College of Biomedical Engineering;Chongqing Key Laboratory of Biomedical Engineering;Chongqing Medical University, Chongqing Collaborative Innovation Center for Minimally-invasive and Noninvasive Medicine, Chongqing 400016, China;
2. National Engineering Research Center of Ultrasound Medicine, Chongqing 401121, China

Received date: 2018-03-21

Online published: 2018-07-16

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摘要

高强度聚焦超声（High Intensity Focused Ultrasound，HIFU）治疗肿瘤时，为了保证治疗的安全性和有效性，需要对组织温度分布进行实时监测.磁共振成像（Magnetic Resonance Imaging，MRI）具有对温度敏感的成像参数，可以无创检测组织温度.本文结合组织相变对测温的影响，探讨了磁共振测温（Magnetic Resonance Thermometry，MRT）技术能否用于实时监控HIFU治疗.利用两态快速交换模型，提出在组织凝固性坏死的相变前后，MRI的纵向弛豫时间（T₁）参数与组织温度之间具有不同关系.并通过实验验证了上述假设.相对于传统的磁共振测温方法模型，本文考虑了HIFU治疗过程中组织相变对检测温度的影响，对利用磁共振测温引导HIFU治疗具有重要的参考价值.

关键词： 高强度聚焦超声(HIFU); 磁共振测温(MRT); 纵向弛豫时间(T₁); 两态快速交换模型

本文引用格式

洪声秀 , 胡红兵 , 杨增涛 , 张天峰 , 黄磊 , 王华 . 组织凝固性坏死对基于纵向弛豫时间的磁共振测温的影响[J]. 波谱学杂志, 2018 , 35(4) : 440 -446 . DOI: 10.11938/cjmr20182624

Abstract

Real-time monitoring of tissue temperature is required during high intensity focused ultrasound (HIFU) tumor treatment to ensure safety and effectiveness. Magnetic resonance imaging (MRI) can be used to measure tissue temperature non-invasively during HIFU treatment. This paper examined the effects of coagulation necrosis-induced tissue phase transition on magnetic resonance thermometry (MRT) during HIFU tumor treatment. With a two-state rapid exchange model, the relationship between tissue longitudinal relaxation time (T₁) and temperature before and after HIFU radiation-induced coagulation necrosis/tissue phase transition were analyzed theoretically. Taking the effects of tissue phase transition into account, the experimental scheme and data processing procedures for MRT were optimized, and better temperature measurements were obtained. The work demonstrated the importance of considering the effects of tissue phase transition in real-time MRT during HIFU treatment.

Key words： high intensity focused ultrasound (HIFU); magnetic resonance thermometry (MRT); longitudinal relaxation time (T₁); two-state rapid exchange model

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