综述评论

脑科学研究中的质子磁共振波谱方法

  • 刘涛涛 ,
  • 王杰 ,
  • 郭向阳
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  • 1. 北京大学第三医院 麻醉科, 北京 100191;
    2. 中国科学院生物磁共振分析重点实验室, 波谱与原子分子物理国家重点实验室, 武汉磁共振中心(中国科学院, 武汉物理与数学研究所), 湖北 武汉 430071

收稿日期: 2018-12-18

  网络出版日期: 2019-04-24

基金资助

国家自然科学基金资助项目(8187051484,8157050329,81600933).

Proton Magnetic Resonance Spectroscopy in Brain Science Researches

  • LIU Tao-tao ,
  • WANG Jie ,
  • GUO Xiang-yang
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  • 1. Department of Anesthesiology, Peking University Third Hospital, Beijing 100191, China;
    2. CAS Key Laboratory of Biomedical Magnetic Resonance Analysis, State Key Laboratory of Magnetic Resonance and Atomic and Molecular Physics, National Center for Magnetic Resonance in Wuhan(Wuhan Institute of Physics and Mathematics, Chinese Academy of Sciences), Wuhan 430071, China

Received date: 2018-12-18

  Online published: 2019-04-24

摘要

核磁共振(NMR)波谱作为一种操作简单、高效且重复性良好的技术手段,在脑科学领域的应用日益广泛,尤其是离体核磁共振氢谱(1H NMR)和活体核磁共振氢谱(1H MRS).1H NMR和1H MRS在实验设计、样品预处理、数据处理等方面各有优劣、各擅胜场.本综述主要从适用范围、样品预处理、数据处理分析等方面,对二者在方法学层面的研究现状进行总结和讨论,以期为脑科学领域的研究者进行大脑代谢相关研究时提供一定的参考和帮助.

本文引用格式

刘涛涛 , 王杰 , 郭向阳 . 脑科学研究中的质子磁共振波谱方法[J]. 波谱学杂志, 2020 , 37(2) : 232 -240 . DOI: 10.11938/cjmr20182702

Abstract

Nuclear magnetic resonance spectroscopy, especially in vivo proton magnetic resonance spectrum (1H MRS) and proton nuclear magnetic resonance (1H NMR), has been increasingly used in brain science researches. There are pros and cons in 1H MRS and 1H NMR with respect to experiment design, sample preparation and data processing. In this review, we summarized and discussed the recent progresses of these two techniques in the ends of application range, sample preparation, quantification and data analysis. The work will provide a reference and insights for neuroscience researchers who are interested in using magnetic resonance spectroscopy for metabolic studies of the brain.

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