新型葫芦[6]脲纳米颗粒超极化129Xe“分子笼”研究

袁晨露; 郭茜旎; 陈世桢; 周欣

doi:10.11938/cjmr20192742

波谱学杂志 >

2019 , Vol. 36 >Issue 4: 472 - 480

DOI: https://doi.org/10.11938/cjmr20192742

研究论文

新型葫芦[6]脲纳米颗粒超极化¹²⁹Xe“分子笼”研究

袁晨露 ,
郭茜旎 ,
陈世桢 ,
周欣

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1. 波谱与原子分子物理国家重点实验室, 武汉磁共振中心(中国科学院武汉物理与数学研究所), 湖北武汉 430071;
2. 中国科学院大学, 北京 100049

收稿日期: 2019-04-26

网络出版日期: 2019-05-30

基金资助

国家自然科学基金资助项目（91859206，81625011）；国家重点研发计划（2016YFC1304704）；中国科学院前沿科学重点研究计划（QYZDY-SSWSLH018）.

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A Novel Molecular Cage for Hyperpolarized ¹²⁹Xe Based on Cucurbit[6]uril Nanoparticles

YUAN Chen-lu ,
GUO Qian-ni ,
CHEN Shi-zhen ,
ZHOU Xin

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1. State Key Laboratory of Magnetic Resonance and Atomic and Molecular Physics, National Center for Magnetic Resonance in Wuhan(Wuhan Institute of Physics and Mathematics, Chinese Academy of Sciences), Wuhan 430071, China;
2. University of Chinese Academy of Sciences, Beijing 100049

Received date: 2019-04-26

Online published: 2019-05-30

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摘要

在相同浓度下，超极化¹²⁹Xe的核磁共振（NMR）灵敏度是传统质子NMR的10 000倍以上，但单原子Xe不具有靶向性，只有单一NMR信号.若超极化¹²⁹Xe与“分子笼”相结合，就能获得新的“笼”内Xe信号，为发展超极化¹²⁹Xe分子探针奠定基础.因此，构建新型的“分子笼”是发展新型超极化¹²⁹Xe分子探针的一个重要方向.葫芦[6]脲纳米颗粒的出现能改善以葫芦[6]脲为主体的¹²⁹Xe分子探针水溶性差、信号弱等缺点.本文构建了水溶性的葫芦[6]脲纳米颗粒，并发现其具有葫芦[6]脲/纳米颗粒内部两个“笼”内¹²⁹Xe信号.这一发现使这种纳米颗粒具有成为超极化¹²⁹Xe分子探针的潜力，能降低检测结果中假阳性和假阴性的发生率，值得更深入的探索和研究.

关键词： 超极化¹²⁹Xe核磁共振; 双信号; 化学交换饱和转移(CEST); 纳米颗粒; 葫芦[6]脲

本文引用格式

袁晨露 , 郭茜旎 , 陈世桢 , 周欣 . 新型葫芦[6]脲纳米颗粒超极化¹²⁹Xe“分子笼”研究[J]. 波谱学杂志, 2019 , 36(4) : 472 -480 . DOI: 10.11938/cjmr20192742

Abstract

Hyperpolarized ¹²⁹Xe NMR has a detection sensitivity up to 10 000 times higher than that in the conventional ¹H NMR. Hyperpolarized ¹²⁹Xe gas has only one NMR signal, but can produce multiple signals when combined with molecular cages, providing the chances to develop targeted molecular probes. In this paper, water-soluble cucurbit[6]uril nanoparticles were used for loading hyperpolarized ¹²⁹Xe gas to construct targeted molecular probes. It was observed that such molecular probes had double "cage" signals and the potential to be developed into multi-functional probes.

Key words： hyperpolarized ¹²⁹Xe nuclear magnetic resonance; chemical exchange saturation transfer (CEST); nanoparticle; cucurbit[6]uril

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