标量偶合是核磁共振（NMR）波谱的一个重要参数.其中氢-氢偶合能提供关于分子结构的有用信息.但是，在复杂的偶合网络中解析出氢-氢偶合常数（JH-H）较为困难.本文提出了一种基于空间编码选择性恒时演化的测量JH-H的方法，利用一次实验就能解析分子中所有氢核的偶合网络，并测量JH-H.该方法被称为同时多层选择性恒时J分解谱（SMS-SECTJRES）.它结合空间编码梯度和选择性恒时演化，并利用平面回波谱成像（EPSI）采样模块，从不同的空间位置提取出对应不同氢核偶合网络的J分解谱，促进了NMR技术在分子结构解析中的进一步应用.
陈金永
,
曾庆
,
林雁勤
,
陈忠
. 用于测量J偶合常数的同时多层选择性恒时J分解谱的方法[J]. 波谱学杂志, 2019
, 36(4)
: 456
-462
.
DOI: 10.11938/cjmr20192775
Scalar coupling is an important parameter in nuclear magnetic resonance (NMR). The proton-proton coupling constant JH-H provides valuable information on molecular structure. However, determining JH-H value in complex coupling networks is still challenging. Here, we propose a method called simultaneous multi-slice selective constant-time J-resolved spectroscopy (SMS-SECTJRES) to measure JH-H values of all coupling networks of a molecule simultaneously in one experiment. In this method, gradient-encoded selective refocusing is used during a fixed evolution time, combined with echo planar spectroscopic imaging (EPSI) detection module to extract different selective J-edited spectra in different spatial positions. This new method is conducive to reveal coupling networks and the analysis of molecular structures.
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