德拉沙星葡甲胺波谱学数据解析
收稿日期: 2020-09-21
网络出版日期: 2020-11-16
Spectroscopic Studies of Delafloxacin Meglumine
Received date: 2020-09-21
Online published: 2020-11-16
赵心怡 , 韩冬 , 罗红军 , 沈文斌 , 杨功俊 . 德拉沙星葡甲胺波谱学数据解析[J]. 波谱学杂志, 2021 , 38(2) : 268 -276 . DOI: 10.11938/cjmr20202855
The structure of delafloxacin meglumine was analyzed by infrared absorption (IR), ultraviolet absorption (UV), nuclear magnetic resonance (1H NMR, 13C NMR, DEPT, 1H-1H COSY, 1H-13C HSQC and 1H-13C HMBC) spectroscopy, mass spectrometry and elemental analysis. The characteristic absorption peaks in the IR spectra were discussed. The 1H and 13C NMR signals of delafloxacin meglumine were assigned, and the two-dimensional signals were used to elucidate its structure. The crystal structure of delafloxacin meglumine was studied by differential scanning calorimetry (DSC), thermogravimetric analysis (TGA) and powder X-ray diffraction (PXRD).
| 1 | CHEN B C. Herald of Medicine, 2018, 37(2): 272-279 |
| 1 | 陈本川. 广谱抗菌新药——德拉沙星葡甲胺(delafloxacin meglumine)[J]. 医药导报, 2018, 37(2): 272-279. |
| 2 | LI S , WANG L , YANG J Y , et al. A novel fluoroquinolone antibiotic for methicillin-resistant staphylococcus aureus: delafloxacin[J]. Chinese Journal of New Drugs, 2018, 27 (19): 2227- 2231. |
| 2 | 李双, 王琳, 杨君义, 等. 抗耐甲氧西林金黄色葡萄球菌的新型氟喹诺酮类药物德拉沙星[J]. 中国新药杂志, 2018, 27 (19): 2227- 2231. |
| 3 | BI H L , ZHANG J Y , LIU X H , et al. A novel broad-spectrum fluoroquinolones antibiotics-delafloxacin[J]. Clinical Medication Journal, 2017, 15 (7): 6- 10. |
| 3 | 毕煌垒, 张佳岳, 刘晓慧, 等. 新型广谱氟喹诺酮类抗菌药物——德拉沙星[J]. 临床药物治疗杂志, 2017, 15 (7): 6- 10. |
| 4 | WANG X B , WANG X L , YUN P H , et al. Synthesis of delaifloxacin meglumine salt[J]. Guangdong Chemical Industry, 2019, 46 (20): 45- 46. |
| 4 | 王兴斌, 王晓龙, 贠盼行, 等. 德拉沙星葡甲胺盐的合成[J]. 广东化工, 2019, 46 (20): 45- 46. |
| 5 | LEMAIRE S , TULKENS P M , VAN BAMBEKE F , et al. Contrasting effects of acidic ph on the extracellular and intracellular activities of the anti-gram-positive fluoroquinolones moxifloxacin and delafloxacin against staphylococcus aureus[J]. Antimicrob Agents Ch, 2011, 55 (2): 649- 658. |
| 6 | IQBAL M , EZZELDIN E , HERQASH R N , et al. Development and validation of a novel UPLC-MS/MS method for quantification of delafloxacin in plasma and aqueous humour for pharmacokinetic analyses[J]. J Chromatog B, 2020, 1138, 121961. |
| 7 | LITWIN J S , BENEDICT M S , THORN M D , et al. A thorough QT study to evaluate the effects of therapeutic and supratherapeutic doses of delafloxacin on cardiac repolarization[J]. AntimicrobAgents Ch, 2015, 59 (6): 3469- 3473. |
| 8 | LIU J H , JIN K , WANG P , et al. An NMR study on esculetin and it's derivatives[J]. Chinese J Magn Reson, 2019, 36 (3): 341- 349. |
| 8 | 刘季红, 靳焜, 王平, 等. 七叶亭及其衍生物的NMR研究[J]. 波谱学杂志, 2019, 36 (3): 341- 349. |
| 9 | WANG Y L , WANG X J , WANG Z W . Spectral analyses and structural elucidation of azilsartan[J]. Chinese J Magn Reson, 2019, 36 (3): 350- 358. |
| 9 | 王亚兰, 王晓静, 王志伟. 阿齐沙坦的波谱学数据及结构确证[J]. 波谱学杂志, 2019, 36 (3): 350- 358. |
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