研究简报

盐酸马尼地平的核磁共振数据解析

  • 李玉江 ,
  • 赵伟 ,
  • 郭晓河 ,
  • 陶乐 ,
  • 张祥 ,
  • 张海艳 ,
  • 赵天增
展开
  • 1. 河南省科学院 高新技术研究中心, 河南 郑州 450002;
    2. 河南省科学院 天然产物重点实验室, 河南 郑州 450002

收稿日期: 2020-09-21

  网络出版日期: 2020-11-20

基金资助

河南省重点研发与推广专项(192102310407).

NMR Data Analysis of Manidipine Hydrochloride

  • LI Yu-jiang ,
  • ZHAO Wei ,
  • GUO Xiao-he ,
  • TAO Le ,
  • ZHANG Xiang ,
  • ZHANG Hai-yan ,
  • ZHAO Tian-zeng
Expand
  • 1. High&New Technology Research Center of Henan Academy of Sciences, Zhengzhou 450002, China;
    2. Key Laboratory of Natural Products, Henan Academy of Sciences, Zhengzhou 450002, China

Received date: 2020-09-21

  Online published: 2020-11-20

摘要

盐酸马尼地平是第三代合成降压新药.本文利用一维、二维核磁共振(NMR)技术,包括1H NMR、13C NMR DEPT-135、1H-1H NOESY、1H-1H COSY、1H-13C HSQC和1H-13C HMBC,对其1H和13C NMR信号进行了全归属,进一步确证了其分子结构.同时,对其1H NMR和13C NMR谱中一些异常信号进行了讨论.

本文引用格式

李玉江 , 赵伟 , 郭晓河 , 陶乐 , 张祥 , 张海艳 , 赵天增 . 盐酸马尼地平的核磁共振数据解析[J]. 波谱学杂志, 2021 , 38(1) : 110 -117 . DOI: 10.11938/cjmr20202853

Abstract

Manidipine hydrochloride is the third generation of new synthetic antihypertensive drugs. The structure of manidipine hydrochloride was confirmed with 1D and 2D nuclear magnetic resonance (NMR) techniques, such as 1H NMR, 13C NMR, DEPT-135, 1H-1H COSY, 1H-1H NOESY, 1H-13C HSQC, and 1H-13C HMBC. Some abnormal signals in 1H NMR and 13C NMR spectra were further discussed.

参考文献

[1] SHIBOUTA Y, KITAYOSHI T, KITOH G, et al. Calcium channel blocking action of franidipine hydrochloride (CV-4093.2HCl) in vitro and in vivo[J]. J Pharmacol Exp Ther, 1988, 48(4):463-472.
[2] LV Y J, CHI X N, GU Z Y. Cosistency evaluation of dissolubility of manidipine hydrochloride tablet generic and original preparation[J]. China Pharmacy, 2015, 26(30):4291-4294.吕亚军,蚩晓娜,谷志勇.盐酸马尼地平片仿制药和原研药的溶出度一致性评价[J].中国药房, 2015, 26(30):4291-4294.
[3] OKABE K, TERADA K, KITAMURA K, et al. Selective and long lasting inhibitory actions of the dihydropyridine derivative, CV-4093, on calcium currents in smooth muscle cells of the rabbit pulmonary artery[J]. J Pharmacol Exp Ther, 1987, 243(2):703-710.
[4] CHEER S M, MCCLELLAN K. Manidipine:a review of its use in hypertension[J]. Drugs, 2001, 61(12):1777-1799.
[5] RICHY F F, LAURENT S. Efficacy and safety profiles of manidipine compared with amlodipine:A meta-analysis of head-to-headtrials[J]. Blood Pressure, 2011, 20(1):54-59.
[6] XIAO F Q, LIU X T, ZHENG Z C, et al. Synthesis of manidipine hydrochloride[J]. Chinese Journal of Pharmaceuticals, 2004, 35(2):65-66.肖方青,刘旭桃,郑正春,等.盐酸马尼地平的合成[J].中国医药工业杂志, 2004, 35(2):65-66.
[7] MEGURO K, AIZAWA M, SOHDA Y, et al. New 1,4-dihydropyridine derivatives with potent and long-lasting hypotensive effect[J]. Chemical & Pharmaceutical Bulletin, 1985, 33(9):3787-3797.
[8] LIU Y, BAI J, ZHAO Z, et al. Effects of methanol and DMSO on assaying illegal addition offluoxetine hydrochloride by 19F-qNMR[J]. Chinese Journal of New Drugs, 2020, 29(2):220-223.刘阳,白洁,赵庄,等.甲醇和二甲基亚砜对19F核磁共振定量法测定盐酸氟西汀非法添加的影响[J].中国新药杂志, 2020, 29(2):220-223.
[9] LU A M, JIANG H M, LV B, et al. Quantitative determination of caffeine in beverages by 1H NMR with internal standard method[J]. Journal of Nanjing Agricultural University, 2014, 37(6):119-124.卢爱民,蒋红梅,吕波,等.核磁共振氢谱内标法测定饮料中咖啡因含量[J].南京农业大学学报, 2014, 37(6):119-124.
[10] XU X J, WANG X Y, ZHAO J Y, et al. The study on quantitative hydrogen nuclear magnetic resonance[J]. Guangdong Chemical Industry, 2020, 4(47):86-88.徐雪晶,万向勇,赵锦漪,等.氢核磁共振定量法初探[J].广东化工, 2020, 4(47):86-88.
[11] WANG Y L, WANG X L, WANG Z W. Spectral analyses and structural elucidation of Azilsartan[J]. Chinese J Magn Reson, 2019, 36(3):350-358.王亚兰,王晓静,王志伟.阿齐沙坦的波谱学数据及结构确证[J].波谱学杂志, 2019, 36(3):350-358.
[12] WANG S H, ZHANG J D, YIN X M, et al. NMR assignments of 6-(4-chlorphenoxy)-tetrazolo[5,1-a]phthalazine[J]. Chinese J Magn Reson, 2020, 37(3):390-398.王思宏,张敬东,尹秀梅,等. 6-(4-氯苯氧基)四唑并[5,1-a]酞嗪的核磁共振谱峰归属[J].波谱学杂志, 2020, 37(3):390-398.
[13] KAJINO M, WADA Y, NAGAI Y, et al. Synthesis and biological activities of optical isomers of 2-(4-diphenylmethyl-1-piperazinyl) ethylmethyl1,4-dihydro-2,6-dimethyl-4-(3-nitrophenyl)-3,5-pyridinedicarboxylate (manidipine) dihydrochloride[J]. Chemical & Pharmaceutical Bulletin, 1989, 37(8):2225-2228.
[14] 赵天增.核磁共振氢谱[M].北京:北京大学出版社, 1983.
[15] 赵天增.核磁共振碳谱[M].郑州:河南科学技术出版社, 1993.
[16] 赵天增,秦海林,张海燕,等.核磁共振二维谱[M].北京:化学工业出版社, 2018.
文章导航

/