基于动态有机钆纳米颗粒的T1-T2双模态MRI造影剂
收稿日期: 2021-03-30
网络出版日期: 2021-05-11
基金资助
科技部“变革性技术关键科学问题”重点专项(2018YFA0704000);国家自然科学基金资助项目(81625011);国家自然科学基金资助项目(91859206);国家自然科学基金资助项目(21921004);国家自然科学基金资助项目(21874150);中国科学院青年创新促进会资助项目(2018365)
Dual-modal MRI T1-T2 Contrast Agent Based on Dynamic Organic Gadolinium Nanoparticles
Received date: 2021-03-30
Online published: 2021-05-11
本文设计、合成并测试了一种新型的基于有机钆纳米颗粒的磁共振成像（MRI）造影剂.以1, 2-氨基硫醇与氰基的缩合反应为基础，成功合成了粒径在8~23 nm范围内的有机钆纳米颗粒.该有机钆纳米颗粒作为磁共振造影剂时，随着时间的推移，其纵向弛豫率逐渐减弱，横向弛豫率先增强后逐渐减弱，这与钆纳米颗粒粒径增大有关.有机钆纳米颗粒同时存在随时间变化的纵向弛豫和横向弛豫，表明它有望成为一种先进的T1-T2双模态MRI造影剂.
关键词： 磁共振成像（MRI）; 造影剂; 双模态; 纳米颗粒
张菊敏 , 陈世桢 , 周欣 . 基于动态有机钆纳米颗粒的T1-T2双模态MRI造影剂[J]. 波谱学杂志, 2022 , 39(1) : 11 -19 . DOI: 10.11938/cjmr20212902
In this work, a new magnetic resonance imaging (MRI) contrast agent based on organic gadolinium (Gd) nanoparticles was designed, synthesized and tested. Based on a biocompatible condensation reaction between 1, 2-aminothiol and cyano group, organic Gd nanoparticles with well-controlled diameter in the range of 8~23 nm were successfully synthesized. When used as the MRI contrast agent, the organic Gd-nanoparticles exhibited slowly weakened longitudinal relaxivity with time. Meanwhile, its transverse relaxivity was observed to be enhanced firstly and then gradually weakened, which could be attributed to the diameter increase of the Gd-nanoparticles. The simultaneous existence of time-dependent longitudinal and transverse relaxivities of the organic Gd-nanoparticles suggests their potential to be advanced T1-T2 dual-modal contrast agent for MRI.
| 1 | TERRENO E , CASTELLI D D , VIALE A , et al. Challenges for molecular magnetic resonance imaging[J]. Chem Rev, 2010, 110 (5): 3019- 3042. |
| 2 | WAHSNER J , GALE E M , RODRíGUEZ-RODRíGUEZ A , et al. Chemistry of MRI contrast agents: current challenges and new frontiers[J]. Chem Rev, 2019, 119 (2): 957- 1057. |
| 3 | QIAO Z , SHI X Y . Dendrimer-based molecular imaging contrast agents[J]. Prog Polym Sci, 2015, 44, 1- 27. |
| 4 | HAASE A . Snapshot FLASH MRI. Applications to T1, T2, and chemical-shift imaging[J]. Magn Reson Med, 1990, 13 (1): 77- 89. |
| 5 | TEGOLA L L , GUGLIELMI G . The role of MRI in rectal cancer: An updated review[J]. Curr Radiol Rep, 2020, |
| 6 | GAO J H , LEI H , CHEN Q , et al. Magnetic resonance imaging: progresses and perspective[J]. Scientia Sinica Vitae, 2020, 50 (11): 1285- 1295. |
| 6 | 高家红, 雷皓, 陈群, 等. 磁共振成像发展综述[J]. 中国科学: 生命科学, 2020, 50 (11): 1285- 1295. |
| 7 | SHELLOCK F G , KANAL E . Safety of magnetic resonance imaging contrast agents[J]. J Magn Reson Imaging, 1999, 10 (3): 477- 484. |
| 8 | HU F Q , ZHAO Y S . Inorganic nanoparticle-based T1 and T1/T2 magnetic resonance contrast probes[J]. Nanoscale, 2012, 4 (20): 6235- 6243. |
| 9 | JIANG W P , WANG Q , ZHOU X . Nuclear magnetic resonance spectroscopy and imaging[J]. Physics, 2013, 42 (12): 826- 837. |
| 9 | 蒋卫平, 王琦, 周欣. 磁共振波谱与成像技术[J]. 物理, 2013, 42 (12): 826- 837. |
| 10 | ?IME?KOVá P , HUBATKA F , KOTOUEK J , et al. Gadolinium labelled nanoliposomes as the platform for MRI theranostics: in vitro safety study in liver cells and macrophages[J]. Sci Rep, 2020, 10 (1): 4780. |
| 11 | LAUER M , LAUER A , YOU S J , et al. Neurotoxicity of subarachnoid Gd-based contrast agent accumulation: a potential complication of intraoperative MRI?[J]. Neurosurg Focus, 2021, 50 (1): E12. |
| 12 | PROMMARAT A , CHAMCHOD F . Pharmacokinetic modeling of Gadolinium nanoparticles (Gd-NPs) with the sojourn time in vasa vasorum for the contrast enhanced MRI[J]. Adv Differ Equ-NY, 2020, 662. |
| 13 | ZENG Q B , GUO Q L , LUO Q , et al. Manganese-based contrast agents for MRI[J]. Chinese J Magn Reson Imaging, 2014, 5 (4): 315- 320. |
| 13 | 曾庆斌, 郭茜旎, 罗晴, 等. 锰对比剂在MRI中的应用[J]. 磁共振成像, 2014, 5 (4): 315- 320. |
| 14 | CARAVAN P , ELLISON J J , MCMURRY T J , et al. Gadolinium(Ⅲ) chelates as MRI contrast agents: structure, dynamics, and applications[J]. Chem Rev, 1999, 99 (9): 2293- 2352. |
| 15 | CHAN K C , FU Q L , GUO H , et al. GD-DTPA enhanced MRI of ocular transport in a rat model of chronic glaucoma[J]. Exp Eye Res, 2008, 87 (4): 334- 341. |
| 16 | RATZINGER G , AGRAWAL P , KORNER W , et al. Surface modification of PLGA nanospheres with Gd-DTPA and Gd-DOTA for high-relaxivity MRI contrast agents[J]. Biomaterials, 2010, 31 (33): 8716- 8723. |
| 17 | YANO K , MATSUMOTO T , OKAMOTO Y , et al. Fabrication of Gd-DOTA-functionalized carboxylated nanodiamonds for selective MR imaging (MRI) of the lymphatic system[J]. Nanotechnology, 2021, 32, 23512. |
| 18 | KUO P H , KANAL E , ABU-ALFA A K , et al. Gadolinium-based MR contrast agents and nephrogenic systemic fibrosis1[J]. Radiology, 2007, 242 (3): 647- 649. |
| 19 | HUANG X , YUAN Y P , RUAN W W , et al. pH-responsive theranostic nanocomposites as synergistically enhancing positive and negative magnetic resonance imaging contrast agents[J]. J Nanobiotechnology, 2018, 16 (1): 30. |
| 20 | REZAEI S J T , MALEKZADEH A M , RAMAZANI A , et al. pH-sensitive magnetite nanoparticles modified with hyperbranched polymers and folic acid for targeted imaging and therapy[J]. Curr Drug Deliv, 2019, 16 (9): 839- 848. |
| 21 | TAN H , XUE J M , SHUTER B , et al. Synthesis of PEOlated Fe3O4@SiO2 nanoparticles via bioinspired silification for magnetic resonance imaging[J]. Adv Funct Mater, 2010, 20 (5): 722- 731. |
| 22 | XIONG C J , YUAN X H , ZHOU J D , et al. Synthesis of folic acid-modified Fe3O4 nano-magnetic fluid for in vivo tumor cell labeling[J]. Afr J Pharm Pharmaco, 2013, 7 (12): 658- 665. |
| 23 | De BRESSER J , BRUNDEL M , CONIJN M , et al. Cerebral microbleed detection on 7 T MRI: Reliability and effects of image processing[J]. Alzheimers Dement, 2011, 7 (4-supp-S): S56- S57. |
| 24 | WU Z , MITTAL S , KISH K , et al. Identification of calcification with MRI using susceptibility-weighted imaging: A case study[J]. J Magn Reson Imaging, 2009, 29 (1): 177- 182. |
| 25 | ALKHUNIZI S M, ABOU-KHEIR W, LAWAND N. MRI contrast agents: evidence of gadolinium metal deposition in the spinal cord and peripheral nerves[C]. Belgrade, Serbia: Federation of European Neuroscience Societies (FENS) Regional Meeting, 2019. |
| 26 | SHAO D D , WANG X X , PAN Z L , et al. Imaging hippocampus of mental patients with BLADE technique[J]. Chinese J Magn Reson, 2019, 36 (3): 261- 267. |
| 26 | 邵丹丹, 王雪雪, 潘自来, 等. 刀锋伪影校正技术在精神疾病患者海马MRI检查中的应用[J]. 波谱学杂志, 2019, 36 (3): 261- 267. |
| 27 | HONG Y , ZHUANG Y M , SUN Y , et al. Targeted dual-contrast T1- and T2-weighted magnetic resonance imaging of tumors using multifunctional gadolinium-labeled superparamagnetic iron oxide nanoparticles[J]. Biomaterials, 2011, 32 (20): 4584- 4593. |
| 28 | KEASBERRY N A , BA OBRE-L PEZ M , WOOD C , et al. Tuning the relaxation rates of dual-mode T1/T2 nanoparticle contrast agents: a study into the ideal system[J]. Nanoscale, 2015, 7 (38): 16119- 16128. |
| 29 | LI F F , ZHI D B , LUO Y F , et al. Core/shell Fe3O4/Gd2O3 nanocubes as T1-T2 dual modal MRI contrast agents[J]. Nanoscale, 2016, 8 (25): 12826- 12833. |
| 30 | SHIN T H , CHOI J S , YUN S , et al. T1 and T2 dual-mode MRI contrast agent for enhancing accuracy by engineered nanomaterials[J]. ACS Nano, 2014, 8 (4): 3393- 401. |
| 31 | WANG L R , LIN H Y , MA L C , et al. Albumin-based nanoparticles loaded with hydrophobic gadolinium chelates as T1-T2 dual-mode contrast agents for accurate liver tumor imaging[J]. Nanoscale, 2017, 9 (13): 4516- 4523. |
| 32 | ZHOU Z J , HUANG D Y , BAO J F , et al. A synergistically enhanced T1-T2 dual-modal contrast agent[J]. Adv Mater, 2012, 24 (46): 6223- 6228. |
| 33 | ZHAO M M , ZHANG Y H , ZHANG P L , et al. A magnetic resonance-fluorescent dual-mode imaging probe for stem cell tracking[J]. Chinese J Magn Reson, 2019, 36 (2): 127- 137. |
| 33 | 赵敏敏, 张艳辉, 张朋利, 等. 一种示踪干细胞的磁共振-荧光双模成像探针[J]. 波谱学杂志, 2019, 36 (2): 127- 137. |
| 34 | LIANG G , RONALD J , CHEN Y , et al. Controlled self-assembling of gadolinium nanoparticles as smart molecular magnetic resonance imaging contrast agents[J]. Angew Chem Int Ed Engl, 2011, 50 (28): 6283- 6286. |
| 35 | ZHANG Y H , ZHANG H Y , ZHANG H L , et al. A new Gd-based T2-weighted magnetic resonance imaging contrast agent: preparation and application in stem cell imaging[J]. Chinese J Magn Reson, 2017, 34 (3): 302- 310. |
| 35 | 张艳辉, 张宏岩, 张海禄, 等. 新型Gd基T2造影剂的制备和应用[J]. 波谱学杂志, 2017, 34 (3): 302- 310. |
/
| 〈 |
|
〉 |