结合局部一致性和低频振幅探究躯体症状障碍患者大脑自发性活动的改变
收稿日期: 2021-03-01
网络出版日期: 2021-06-02
基金资助
国家自然科学基金资助项目(81571658)
A Study on the Alteration of Spontaneous Brain Activity in Somatic Symptoms Disorder Combining Regional Homogeneity and Amplitude of Low-frequency Fluctuation
Received date: 2021-03-01
Online published: 2021-06-02
躯体症状障碍（somatic symptom disorder，SSD）是一种常见的医学疾病，致病原因涉及生物学、心理学及社会因素.目前关于SSD的神经机制知之甚少.本研究通过静息态功能磁共振成像（functional magnetic resonance imaging，fMRI），结合低频振幅（amplitudes of low-frequency fluctuation，ALFF）和局部一致性（regional homogeneity，ReHo）分析探究45位SSD患者和43位健康对照自发性脑活动特征的区别.结果发现：与对照组相比，SSD患者右侧扣带回中部的ReHo值显著升高，而右侧楔前叶、左侧颞下回延伸到左侧颞中回和左侧海马旁回、右侧脑桥的ReHo值显著降低.同时，SSD患者扣带回中部延伸至左侧额中回、右侧脑岛延伸至右侧额下回、左侧额中回延伸至左侧前扣带回的ALFF值均显著升高.这些脑区的脑功能与自我加工、情绪处理、身体知觉等有关，与SSD发病机制有重要联系.
关键词： 躯体症状障碍（SSD）; 局部一致性; 低频振幅（ALFF）; 功能磁共振成像（fMRI）
崔阳阳 , 梁怀彬 , 朱千 , 汤伟 , 高婷婷 , 刘建仁 , 杜小霞 . 结合局部一致性和低频振幅探究躯体症状障碍患者大脑自发性活动的改变[J]. 波谱学杂志, 2022 , 39(1) : 64 -71 . DOI: 10.11938/cjmr20212894
Somatic symptom disorder (SSD) is a common medical disorder characterized by various biological, psychological, and social pathogenic factors. At present, little is known about the neural mechanism of SSD. This study evaluated the dysfunction in 45 patients with SSD and 43 controls by combining the amplitudes of low-frequency fluctuation (ALFF) and regional homogeneity (ReHo) methods with resting-state functional magnetic resonance imaging (fMRI). The patients with SSD exhibited significantly greater ReHo values in the right middle cingulate gyrus, and smaller ReHo values in the right precuneus, the left inferior temporal gyrus extending to the left middle temporal gyrus and the left parahippocampal gyrus, and the right pons compared with the controls. The SSD patients showed higher ALFF values in the middle cingulate gyrus extending to the left middle frontal gyrus, the right insula extending to the right inferior frontal gyrus, and left middle frontal gyrus extending to the left anterior cingulate cortex. These dysfunction areas are involved in self-relevant processes, emotional processing, and body perception, which are closely related to the pathogenesis of SSD.
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