T2/FLAIR错配征的定量参数在评价较低级别胶质瘤分子分型的诊断价值
收稿日期: 2021-03-23
网络出版日期: 2021-06-29
基金资助
国家自然科学基金青年科学基金资助项目(81701661)
The Diagnostic Value of Quantitative Parameters of T2/FLAIR Mismatch Sign in Evaluating the Molecular Typing of Lower-grade Gliomas
Received date: 2021-03-23
Online published: 2021-06-29
本文回顾性分析19例经病理证实为WHO Ⅱ-Ⅲ级且具有T2/FLAIR错配征的脑胶质瘤患者.从患者的影像数据中提取肿瘤区整体特征和错配区影像参数进行定量分析，探讨T2/FLAIR错配征在评价异柠檬酸脱氢酶（IDH）突变伴1p/19q未联合缺失型（IDHMUT/1p/19q+）较低级别胶质瘤（LGG）的诊断效能.本研究表明，整体及部分T2/FLAIR错配征可作为预测IDHMUT/1p/19q+ LGG的影像标志物.肿瘤区整体影像特征联合错配区定量参数有助于提高对IDHMUT/1p/19q+ LGG的诊断效能.
关键词： 磁共振成像（MRI）; T2/FLAIR错配征; 分子分型; 较低级别胶质瘤; 定量参数
王瀚苇 , 吴昊 , 田静 , 张俊峰 , 钟鹏 , 陈立朝 , 王舒楠 . T2/FLAIR错配征的定量参数在评价较低级别胶质瘤分子分型的诊断价值[J]. 波谱学杂志, 2022 , 39(1) : 56 -63 . DOI: 10.11938/cjmr20212899
This paper performed a retrospective analysis of 19 patients diagnosed with pathologically-verified WHO Ⅱ-Ⅲ grade glioma with T2/FLAIR mismatch sign. We extracted the overall characteristics of the tumor area and the image parameters of the mismatch regions from the patients' imaging data for quantitative analysis. Afterward, we investigated how T2/FLAIR mismatch sign affected the diagnostic efficacy for isocitrate dehydrogenase (IDH)-mutant and 1p/19q non-codeleted (IDHMUT/1p/19q+) lower-grade gliomas (LGG). This study showed that the overall and partial T2/FLAIR mismatch sign can be used as an imaging marker to predict IDHMUT/1p/19q+ LGG. The overall imaging characteristics of the tumor area combined with the quantitative parameters of the mismatch regions can improve the diagnostic efficacy for IDHMUT/1p/19q+ LGG.
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