超极化129Xe自动收集-升华装置研究
收稿日期: 2022-04-14
网络出版日期: 2022-05-12
基金资助
国家自然科学基金资助项目(11905288);国家自然科学基金资助项目(82127802)
Study on the Automatic Accumulation-thawing Device of Hyperpolarized 129Xe
Received date: 2022-04-14
Online published: 2022-05-12
因其较高的核自旋极化度所提供的探测灵敏度，超极化129Xe气体已被成功应用于动物和人体磁共振成像（MRI）.但是，在超极化129Xe的收集-升华过程中，多种因素会导致129Xe核自旋弛豫，进而限制其应用范围.本文通过理论模型分析和实验测量，验证了温度、磁场、螺旋冷阱材质等对冷冻恢复过程中超极化129Xe弛豫的影响；同时，测量了自动收集-升华装置的稳定性.研究结果表明，升华方式和冷阱材质对129Xe极化度损耗的影响显著；自制收集-升华装置的自动化程度高、长时间稳定，129Xe极化度的恢复率可达到85.6% ± 4.7%.本研究非常有助于提升超极化129Xe在动物和人体MRI中的使用效率.
关键词： 磁共振成像; 超极化129Xe气体; 自动收集-升华装置; 极化度恢复率
陈小明 , 赵修超 , 孙献平 , 谢军帅 , 李海东 , 韩叶清 , 刘小玲 , 陈琪 , 周欣 . 超极化129Xe自动收集-升华装置研究[J]. 波谱学杂志, 2022 , 39(3) : 316 -326 . DOI: 10.11938/cjmr20222998
Due to the detection sensitivity provided by the high nuclear spin polarization, hyperpolarized 129Xe has been employed in animal and human magnetic resonance imaging (MRI). However, during the accumulation-thawing process of hyperpolarized 129Xe, multiple factors lead to the relaxation of spin polarization and would hinder the wider application of 129Xe. In this research, the spin relaxation mechanism of hyperpolarized 129Xe during the accumulation-thawing process is investigated by both theoretical model analysis and experimental measurements. Meanwhile, the stability of the homebuilt device for the accumulation-thawing is measured. Our results demonstrate that the thawing mode and the cold trap material significantly affect the polarization loss; the automatic device is very stable during long-term operation and shows a high degree of automation, resulting in a polarization recovery ratio of 85.6% ± 4.7%. This research greatly helps to improve the efficiency of hyperpolarized 129Xe in animal and human MRI.
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