分子影像新技术——氘代谢波谱及成像的综述与展望
收稿日期: 2022-04-15
网络出版日期: 2022-06-13
基金资助
国家重点研发计划项目(2018YFA0701400);国家自然科学基金资助项目(81701774);国家自然科学基金资助项目(61771423)
Review of a New Molecular Imaging Method——Deuterium Metabolic Spectroscopy and Imaging
Received date: 2022-04-15
Online published: 2022-06-13
目前常用的分子影像技术主要有正电子发射型断层显像（PET）、质子磁共振波谱（1H MRS）及成像（1H MRSI）、化学交换饱和转移（CEST）、超极化13C MRSI等.近4年来，氘代谢波谱（DMS）及成像（DMI）作为一种新兴的分子影像技术获得了越来越多的关注，其通过采集注射或口服氘代葡萄糖后的目标组织与正常组织间氘代谢产物的磁共振信号进行组织区分.相比于其他分子影像方法，该影像技术具有无辐射、稳定性好、扫描操作相对简单等优点.本文综述了近年来DMS/DMI技术的研究进展及其意义，归纳总结了其临床应用价值，并对该技术未来的发展和改进方向，以及应用前景进行了展望.
张怡 , 楼飞洋 , 方可 , 陈高 , 张孝通 . 分子影像新技术——氘代谢波谱及成像的综述与展望[J]. 波谱学杂志, 2022 , 39(3) : 356 -365 . DOI: 10.11938/cjmr20222999
Commonly used molecular imaging methods include positron emission tomography (PET), hydrogen magnetic resonance spectroscopy (1H MRS) and imaging (1H MRSI), chemical exchange saturation transfer (CEST), and hyperpolarized 13C MRSI. As a cutting-edge molecular imaging method, deuterium metabolic spectroscopy (DMS) and imaging (DMI) has been recently developed and it distinguishes different tissues according to their specific glycometabolism. Compared with other molecular imaging methods, this promising technique has apparent advantages such as no radioactivity, good stability, and easy to maneuver. In this article, we review the progress of DMS/DMI and discuss its significance, future development, and potential clinical applications.
Key words： magnetic resonance; metabolic imaging; glucose; deuterium; tumor
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