用于小口径5 T磁共振成像系统的梯度线圈和1H/13C双共振射频线圈研制
收稿日期: 2024-03-13
网络出版日期: 2024-03-29
基金资助
国家重点研发计划项目(2023YFE0113300);国家重点研发计划项目(2022YFF0707000);中国科学院磁共振技术联盟科研仪器设备研制项目(2021-GZL001);中国科学院基础与交叉前沿科研先导专项(XDB0540300);国家自然科学基金项目(22327901);国家自然科学基金项目(81627901);国家自然科学基金项目(22374158);国家自然科学基金项目(22127801);国家自然科学基金项目(21927801);国家自然科学基金项目(12205352);国家自然科学基金项目(22204168);中国科学院精密测量科学与技术创新研究院交叉培育项目(S21S4101);中国科学院科研仪器研制项目(YJKYYQ20190032)
Development of Gradient Coils and 1H/13C Dual-resonance RF Coils for a Small-bore 5 T MRI System
Received date: 2024-03-13
Online published: 2024-03-29
基于自主研制的5 T磁共振成像系统和13C代谢磁共振成像研究需求，设计了一种小口径磁共振成像梯度线圈和1H/13C双共振射频线圈系统．其中梯度线圈设计采用有限差分流函数方法，射频线圈设计为马鞍线圈结合表面线圈的双共振方案．采用有限元方法对磁场分布进行了数值模拟分析，成功研制出一套用于小口径5 T 13C磁共振成像的梯度与射频线圈，并利用自主研制的5 T磁共振成像系统平台验证了设计方案的可行性，经过实验测试采集到13C标记的尿素水模磁共振图像和小鼠头部1H磁共振图像，为后续开展基于动态核极化的13C磁共振代谢成像奠定了基础．
关键词： 高场磁共振成像; 13C代谢磁共振成像; 梯度线圈; 1H/13C双共振线圈; 马鞍线圈; 表面线圈
易鹏 , 曹丽 , 黄臻 , 程鑫 , 王佳鑫 , 陈黎 , 陈方 , 鲍庆嘉 , 张志 , 刘朝阳 . 用于小口径5 T磁共振成像系统的梯度线圈和1H/13C双共振射频线圈研制[J]. 波谱学杂志, 2024 , 41(3) : 245 -256 . DOI: 10.11938/cjmr20243100
Based on the independently developed 5 T magnetic resonance imaging (MRI) system and research needs of 13C metabolic MRI, a gradient coil and 1H/13C dual resonance radiofrequency (RF) coil system for small-bore MRI were designed. The gradient coil was designed by using the finite-difference stream function method, and the RF coil was designed as a saddle coil combined with a surface coil in a dual-resonance scheme. Numerical simulation analysis of the magnetic field distribution was carried out by using the finite-element method, and a set of gradient and RF coils for small-bore 5 T 13C MRI was successfully developed. The feasibility of the design scheme was verified using a home-made 5 T MRI system, and the magnetic resonance images of 13C-labeled urea phantom and 1H magnetic resonance images of mice head were acquired by experimental tests, which lays a foundation for 13C metabolic MRI based on dynamic nuclear polarization in the future.
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