扩散加权磁共振波谱采集策略优化：门控及循环模式影响
收稿日期: 2025-04-02
网络出版日期: 2025-05-12
基金资助
国家科技创新2030项目(2021ZD0200500);上海市科学技术委员会项目(YDZX20243100003001001)
Optimization of DW-MRS Acquisition Protocol: The Impact of Gating and Cycling Modes
Received date: 2025-04-02
Online published: 2025-05-12
扩散加权磁共振波谱（DW-MRS）可用于测量代谢物表观扩散系数（ADC），从而特异性地表征细胞微结构特性. 然而，生理运动伪影和较低的测量重复性限制了其临床应用. 本文探究了不同门控方法和循环模式对DW-MRS结果的影响. 研究共纳入21名健康受试者，其中6名分别采用心电门控、呼吸门控和无门控策略对辐射冠及后扣带回皮层区域进行扫描，对比信号衰减情况；另15名分别使用b值内循环与外循环模式进行扫描，评估循环模式对ADC测量可重复性的影响. 结果表明，心电门控可显著抑制生理运动伪影并降低ADC高估现象，且在辐射冠区域效果尤为明显，而呼吸门控的改善作用相对有限. 此外，b值内循环可提升ADC可重复性. 因此，结合心电门控与b值内循环技术可有效降低运动伪影，提高ADC可靠性，为DW-MRS临床应用提供技术支持.
文玉林 , 李改英 , 武玉朋 , 李建奇 . 扩散加权磁共振波谱采集策略优化：门控及循环模式影响[J]. 波谱学杂志, 2025 , 42(4) : 402 -413 . DOI: 10.11938/cjmr20253156
Diffusion-weighted magnetic resonance spectroscopy (DW-MRS) measures metabolite apparent diffusion coefficients (ADC) to characterize cellular microstructures. However, physiological motion artifacts and low reproducibility limit its clinical application. This study investigates the effects of different gating methods and cycling modes on DW-MRS results. A total of 21 healthy subjects were included: 6 underwent DW-MRS scans under electrocardiogram (ECG) gating, respiratory gating, and no gating; the remaining 15 were scanned using internal and external b-value cycling to evaluate the impact of cycling modes on ADC reproducibility. Results showed that ECG gating reduced motion artifacts and mitigated ADC overestimation, while internal cycling improved reproducibility. The combination of ECG gating and internal cycling enhances ADC reliability, supporting the broader clinical application of DW-MRS.
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