19F NMR化学位移编码的cRGD靶向双模态探针多色成像
收稿日期: 2025-11-05
网络出版日期: 2026-08-11
基金资助
国家自然科学基金项目(U21A20392);国家自然科学基金项目(82127802);国家自然科学基金项目(22404064);国家自然科学基金项目(82102125);湖北省自然科学基金项目(2023BCB092);中国科学院青年跨学科团队项目(JCTD-2022-13)
19F NMR Chemical Shift-encoded cRGD-targeted Dual-modal Probe for Multicolor Imaging
Received date: 2025-11-05
Online published: 2026-08-11
李娜 , 肖龙 , 李莎 , 刘昱墩 , 贾宇舒 , 张磊 , 陈世桢 . 19F NMR化学位移编码的cRGD靶向双模态探针多色成像[J]. 波谱学杂志, 2026 , 43(3) : 279 -290 . DOI: 10.11938/cjmr20253189
Specific imaging of the tumor microenvironment is critical for precise cancer diagnosis, yet conventional single-modal imaging techniques struggle to combine high sensitivity with high spatial resolution. This study designed and synthesized a cRGD peptide-targeted, nitroreductase (NTR)-responsive hemicyanine-19F dual-modal probe, Cy-F-cRGD. Through systematic screening of different fluorine-containing groups, we found that an ortho-difluoro structure induced a remarkable 19F chemical shift change (ΔδF = 10.87). Concurrently, the hemicyanine unit exhibited an 80 nm red shift in absorption and a 90-fold fluorescence enhancement, achieving an optical “off-on” signal switch. This work offers a new design strategy for developing smart responsive multimodal probes.
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