洛莫司汀的1H、13C NMR全归属
收稿日期: 2015-05-19
修回日期: 2016-04-15
网络出版日期: 2016-06-05
基金资助
陕西省自然科学基金资助项目(2010JM2001).
An NMR Study on Lomustine
Received date: 2015-05-19
Revised date: 2016-04-15
Online published: 2016-06-05
孙伟 , 高翔 , 郭娟 , 余向阳 . 洛莫司汀的1H、13C NMR全归属[J]. 波谱学杂志, 2016 , 33(2) : 353 -359 . DOI: 10.11938/cjmr20160217
Lomustine is an important drug having chiral carbon atoms. In the present study, one-dimensional 1H and 13C NMR, as well as two-dimensional techniques (i.e., 1H-13C HMBC, 1H-13C HSQC, 1H-1H COSY and 1H-1H NOESY) were used to elucidate the structure of Lomustine. The proton and carbon chemical shifts of the compound were assigned.
Key words： NMR; assignment; Lomustine
[1] William L, Shive M S. Synthesis of specifically 15N- and 13C-labeled a ntitumor (2-Haloethyl)nitrosoureas. The study of their conformations in solution by nitrogen-15 and carbon-13 nuclear magnetic resonance and evidence for stereoelectronic control in their aqueous decomposition[J]. J Org Chem, 1981, 46:5309-5321.
[2] Su Jun(苏军), Meng Qing-wei(孟庆伟), Zhao Wei-jie(赵伟杰), et al. Synthesis of lomustine utilizing triphosgene(固体光气法合成洛莫司汀)[J]. Chinese J Med Chem(中国药物化学杂志), 2003, 13(3):170-171.
[3] Jiang Hong(蒋虹), Wang Qiang(王强), Liu Xin-you(刘新友). A new derivative of hexahydroquinolin studied by NMR spectroscopy(一种新的六氢喹啉衍生物的NMR研究)[J]. Chinese J Magn Reson(波谱学杂志), 2007, 24(1):9-15.
[4] Sun Wei(孙伟), Wei Yong-feng(魏永锋), Bai Yin-juan(白银娟), et al. An NMR study of α-mangostin(α-山竹黄酮的NMR研究)[J]. Chinese J Magn Reson(波谱学杂志), 2008, 25(2):257-264.
[5] Zhao Yu-mei(赵玉梅), Liu Li-jun(刘力军), Miao Zhen-chun(缪振春). Structural determination of an aglycome by long-range DEPT and selective NOESY techniques(选择性远程DEPT和选择性NOESY技术用于苷类化合物的结构研究)[J]. Chinese J Magn Reson(波谱学杂志), 2008, 25(3):342-348.
[6] Yang Xiu-wei(杨秀伟). Application of NMR for structural dedication of forbesoside(应用2D NMR技术研究羌活苷的结构)[J]. Chinese J Magn Reson(波谱学杂志), 2006, 23(4):429-441.
[7] Tan Xiao-jian(谭小健), Wang Hai-Qing(王海顷), Jiang Hua-liang(蒋华良), et al. Structure assignment of 8α-OH phlegmariurine B(8α-OH马尾杉碱B的结构鉴定)[J]. Acta Chimica Sinica(化学学报), 2000, 58(11):1386-1392.
[8] Zuo Ai-hua(左爱华), Chen Meng-chun(程孟春), Zhuo Rong-jie(卓荣杰), et al. Structure elucidation of degradation products of Z-ligustilide by UPLC-QTOF-MS and NMR spectroscopy(Z-藁本内酯降解产物的UPCL-QTOF-MS和NMR结构鉴定)[J]. Acta Pharmaceutica Sinica(药学学报), 2013, 48(6):911-916.
/
| 〈 |
|
〉 |