磁共振仪器研制技术进展专栏

便携式核磁共振谱仪的研究进展

  • 刘敏 ,
  • 邱雯绮 ,
  • 孙惠军* ,
  • 陈忠
展开
  • 厦门大学 电子科学系,福建省等离子体与磁共振研究重点实验室,福建 厦门 361005
刘敏(1987-),男,福建宁德人,硕士研究生,电子与通信工程专业,主要研究方向为磁共振仪器和方法. *通讯联系人:孙惠军,电话:0592-2183301,E-mail:sunhj@xmu.edu.cn.

收稿日期: 2014-04-16

  修回日期: 2014-10-29

  网络出版日期: 2014-12-05

基金资助

国家自然科学基金资助项目(21327001).

Progress in the Portable NMR Spectrometer

  • LIU Min ,
  • QIU Wen-qi ,
  • SUN Hui-jun* ,
  • CHEN Zhong
Expand
  • Department of Electronic Science, Fujian Key Laboratory of Plasma and Magnetic Resonance, Xiamen University, Xiamen 361005, China
*Corresponding author:SUN Hui-jun, Tel: 0592-2183301, E-mail: sunhj@xmu.edu.cn.

Received date: 2014-04-16

  Revised date: 2014-10-29

  Online published: 2014-12-05

Supported by

国家自然科学基金资助项目(21327001).

摘要

与超导核磁共振谱仪相比,便携式核磁共振谱仪虽然在灵敏度和分辨率方面存在不足,但是其在快速现场检测方面具有明显的优势和广阔的应用前景.近年来,新技术和新方法的出现有效提高了便携式NMR 谱仪的分析能力,使得它更具实用性.该文介绍了便携式NMR 谱仪在核心软硬件、高分辨实验方法和实际应用等方面的最新进展,并对以后的发展方向进行了展望.

本文引用格式

刘敏 , 邱雯绮 , 孙惠军* , 陈忠 . 便携式核磁共振谱仪的研究进展[J]. 波谱学杂志, 2014 , 31(4) : 504 -514 . DOI: 10.11938/cjmr20140405

Abstract

Although the portable NMR spectrometers usually have lower signal-to-noise (SNR) and resolution compared to superconducting nuclear magnetic resonance (NMR) spectrometers, they show great advantages in more practical applications, such as fast on-site testing. In recent years, the rapid advances in hardware and experimental methods improved portable NMR spectrometers considerably, in terms of both robustness and analysis ability. This paper introduces recent progresses of portable NMR spectrometers in several aspects: hardware and software developments, high-resolution experimental methods, applications, and prospective on their future development.

参考文献

[1] Mitchell J, Gladden L F, Chandrasekera T C, et al. Low-field permanent magnets for industrial process and quality control[J]. Prog Nucl Magn Reson Spectrosc, 2014, 76: 1-60.

[2] Xiao L Z, Liu H B, Deng F, et al. Probing internal gradients dependence in sandstones with multi-dimensional NMR[J]. Micropor Mesopor Mat, 2013, 178: 90-93.

[3] Honorato H D A, Silva R C, Piumbini C K, et al. 1H low- and high-field NMR study of the effects of plasma treatment on the oil and water fractions in crude heavy oil[J]. Fuel, 2012, 92(1): 62-68.

[4] Castro C M, Ghazani A A, Chung J, et al. Miniaturized nuclear magnetic resonance platform for detection and profiling of circulating tumor cells[J]. Lab Chip, 2014, 14(1): 14-23.

[5] Lee H, Sun E, Ham D. Chip-NMR biosensor for detection and molecular analysis cells[J]. Nat Med, 2008, 14(8): 869-874.

[6] Sun N, Yoon T J, Lee H, et al. Plam NMR and 1-chip NMR[J]. IEEE J Solid-St Circ, 2011, 46(1): 342-352.

[7] Badilita V, Meier R C, Spengler N, et al. Microscale nuclear magnetic resonance: a tool for soft matter research[J]. Royal Soc Chem, 2012, 8(41): 10 583-10 597.

[8] Turek K, Liszkowski P. Magnetic field homogeneity perturbations in finite Halbach dipole magnets[J]. J Magn Reson, 2014, 238: 52-62.

[9] Halbach K. Design of permanent multipole magnets with oriented rare earth cobalt materials[J]. Nucl Instrum Meth, 1980, 169(1): 1-10.

[10] Zhang Yi-ming(张一鸣), Qiao De-zhi(乔德治), Gao Jun-xia(高俊侠). Current research on and applications of Halbach permanent magnet array (Halbach 阵列永磁体的研究现状与应用)[J]. Anal Instrum(分析仪器), 2010, 2: 5-10.

[11] Danieli E, Perlo J, Blümich B, et al. Small magnets for portable NMR spectrometers[J]. Angew Chem Int Edit, 2010, 49(24): 4 133-4 135.

[12] Chen J Z, Xu C Y. An improved discrete configuration of a cylinder magnet for portable nuclear magnetic resonance instruments[J]. J Appl Phys, 2007, 101(12): 123926.

[13] Liu W, Casanova F, Blümich B, et al. An efficacious target-field approach to design shim coils for Halbach magnet of mobile NMR sensors[J]. Appl Magn Reson, 2012, 42(1): 101-112.

[14] Wang Q Y, Zheng L, An S Z, et al. Thermal stability of surface modified Sm2Co17-type high temperature magnets[J]. J Magn Magn Mater, 2013, 331: 245-249.

[15] Jones C J, Larive C K. Could smaller really be better? Current and future trends in high-resolution microcoil NMR spectroscopy[J]. Anal Bioanal Chem, 2012, 402(1): 61-68.

[16] Watzlaw J, Müntjes J, Mokwa W, et al. Multilayer micro coils for thin film analysis with mobile NMR arrays[J]. Procedia Eng, 2011, 25: 395-398.

[17] Demas V, Herberg J L, Malba V, et al. Portable, low-cost NMR with laser-lathe lithography produced microcoils[J]. J Magn Reson, 2007, 189(1): 121-129.

[18] Gruschke O G, Baxan N, Clad L, et al. Lab on a chip phased-array MR multi-platform analysis system[J]. Lab Chip, 2012, 12(3): 495-502.

[19] Takeda K. OPENCORE NMR: Open-source core modules for implementing an integrated FPGA-based NMR spectrometer[J]. J Magn Reson, 2008, 192(2): 218-229.

[20] Tang W N, Wang W M. A single-board NMR spectrometer based on a software defined radio architecture[J]. Meas Sci Technol, 2011, 22(1): 015902.

[21] Liu Ying(刘颖), Shen Jie(沈杰), Li Geng-ying(李鲠颖). Integrated nuclear magnetic resonance spectrometer based on USB connection(基于USB 总线的一体化核磁共振谱仪控制台)[J]. Chinese J Magn Reson(波谱学杂志), 2007, 24(1): 35-41.

[22] Thermo Fisher Scientific. PicoSpin-80[EB/OL]. http://picospin.com/products/picospin-80/.

[23] Li QY. Touch NMR[EB/OL]. https://itunes.apple.com/app/touch-nmr/id564986048?mt=8.

[24] Wu Rui(吴瑞), Zhang Zhi-yong(张志勇), Chen Hao(陈浩), et al. Progress of ultrafast spatially encoded high-resolution nuclear magnetic resonance spectroscopy in inhomogeneous fields(不均匀场下空间编码超快速高分辨NMR 研究进展)[J]. Chinese J Magn Reson(波谱学杂志), 2013, 30(3): 430-446.

[25] Lin Y L, Zhang Z Y, Cai S H, et al. High-resolution 2D J-resolved spectroscopy in inhomogeneous fields with two scans[J]. J Am Chem Soc, 2011, 133(20): 7 632-7 635.

[26] Huang Y Q, Cai S H, Chen X, et al. Intermolecular single-quantum coherence sequences for high-resolution NMR spectra in inhomogeneous fields[J]. J Magn Reson, 2010, 203(1): 100-107.

[27] Franck J M, Demas V, Martin R W, et al. Shimmed matching pulses: Simultaneous control of RF and static gradients for inhomogeneity correction[J]. J Chem Phys, 2009, 131(23): 234506.

[28] Perlo J, Demas V, Casanova F, et al. High-resolution NMR spectroscopy with a portable single-sided sensor[J]. Science, 2005, 308(5 726): 1279.

[29] Shapira B, Frydman L. Spatially encoded pulse sequences for the acquisition of high resolution NMR spectra in inhomogeneous fields[J]. J Magn Reson, 2006, 182(1): 12-21.

[30] Zhang Z Y, Chen H, Wu C, et al. Spatially encoded ultrafast high-resolution 2D homonuclear correlation spectroscopy in inhomogeneous fields[J]. J Magn Reson, 2013, 227: 39-45.

[31] Shapira B, Frydman L. Spatial encoding and the acquisition of high-resolution NMR spectra in inhomogeneous magnetic fields[J]. J Am Chem Soc, 2004, 126(23): 7 184-7 185.

[32] Iijima T, Takegoshi K, Hashi K, et al. High-resolution NMR with resistive and hybrid magnets: Deconvolution using a field-fluctuation signal[J]. J Magn Reson, 2007, 184(2): 258-262.

[33] Theis T, Blanchard J W, Butler M C, et al. Chemical analysis using J-coupling multiplets in zero-field NMR[J]. Chem Phys Lett, 2013, 580: 160-165.

[34] Blümich B, Casanova F, Appelt S. NMR at low magnetic fields[J]. Chem Phys Lett, 2009, 477(4): 231-240.

[35] Katz I, Shtirberg L, Shakour G, et al. Earth field NMR with chemical shift spectral resolution: Theory and proof of concept[J]. J Magn Reson, 2012, 219: 13-24.

[36] Ledbetter M P, Theis T, Blanchard J W, et al. Near-zero-field nuclear magnetic resonance[J]. Phys Rev Lett, 2011, 107(10): 107601.

[37] Andersen C M, Frøst M B, Viereck N. Spectroscopic characterization of low- and non-fat cream cheeses[J]. Int Dairy J, 2010, 20(1): 32-39.

[38] Hansen C L, Thybo A K, Bertram H C, et al. Determination of dry matter content in potato tubers by low-field nuclear magnetic resonance(LF-NMR)[J]. J Agr Food Chem, 2010, 58(19): 10 300-10 304.

[39] Pearce K L, Rosenvold K, Andersen H J, et al. Water distribution and mobility in meat during the conversion of muscle to meat and ageing and the impacts on fresh meat quality attributes-a review[J]. Meat Sci, 2011, 89 (2): 111-124.

[40] Erikson U, Standal I B, Aursand I G, et al. Use of NMR in fish processing optimization:a review of recent progress[J]. Magn Reson Chem, 2012, 50(7): 471-480.

[41] Lucas T, Wagener M, Barey P, et al. NMR assessment of mix and ice cream. Effect of formulation on liquid water and ice[J]. Int Dairy J, 2005, 15(10): 1 064-1 073.

[42] Meng Xiao-hai(孟小海), Jiang Zhi-min(姜志敏), Shi Jing-sheng(史京生), et al. Two-dimensional NMR spectroscopy for observing rock wettability(二维核磁共振观测岩石润湿性)[J]. Chinese J Magn Reson(波谱学杂志), 2012, 2(29): 190-200.

[43] Simina M, Molnar L, Manea D, et al. Monitoring the air influence on cement-lime mortar hydration using low-field nuclear magnetic resonance relaxometry[J]. Appl Magn Reson, 2012, 43(3): 443-450.

[44] Proietti N, Presciutti F, Di Tullio V, et al. Unilateral NMR, 13C CPMAS NMR spectroscopy and micro-analytical techniques for studying the materials and state of conservation of an ancient Egyptian wooden sarcophagus[J]. Anal Bioanal Chem, 2011, 399(9): 3 117-3 131.

[45] Blümich B, Haber A, Casanova F, et al. Noninvasive depth profiling of walls by portable nuclear magnetic resonance[J]. Anal Bioanal Chem, 2010, 397(7): 3 117-3 125.

[46] Capitani D, Brilli F, Mannina L, et al. In situ investigation of leaf water status by portable unilateral nuclear magnetic resonance[J]. Plant Physiol, 2009, 149(4): 1 638-1 647.

文章导航

/