先进固体核磁共振揭示苯硼酸-壳聚糖纳米粒子非均匀结构和相容性
收稿日期: 2015-02-11
修回日期: 2015-05-08
网络出版日期: 2015-06-05
基金资助
The National Natural Science Foundation of China (20825416, 21374051).
Heterogeneous Structure and Miscibility of Phenylboronic Acid-Rich Chitosan Nanoparticles as Revealed by Advanced Solid-State NMR
Received date: 2015-02-11
Revised date: 2015-05-08
Online published: 2015-06-05
Supported by
The National Natural Science Foundation of China (20825416, 21374051).
王粉粉 1 , 陈铁红1 , 孙平川1 , 2 , 3* . 先进固体核磁共振揭示苯硼酸-壳聚糖纳米粒子非均匀结构和相容性[J]. 波谱学杂志, 2015 , 32(2) : 354 -362 . DOI: 10.11938/cjmr20150217
By using advanced solid-state NMR techniques, the heterogeneous structure and inter-polymer miscibility of chitosan-poly (N-3-acrylamidophenyl-boronic acid) nanoparticles (CS-PAPBA NPs) were investigated. The 13C CPMAS experiments indicate the conformational change of chitosan when incorporated with phenyl boronic acid. Two-dimensional (2D) 13C-1H HETCOR experiments further demonstrate that a portion of chitosan is closely bound with
PAPBA in the interphase by means of boronic coordination interaction. 2D 1H-1H spin-exchange with spin-diffusion experiments demonstrate that the interfacial mixing of chitosan and PAPBA, and micro-phase separation is of the order of 15–20 nanometers.
Key words： solid-state NMR; heterogeneous structure; miscibility; nanoparticles; chitosan
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