富马酸替诺福韦二吡呋酯波谱数据与结构确证
收稿日期: 2014-10-11
修回日期: 2015-07-21
网络出版日期: 2015-09-05
基金资助
沈阳药科大学大学生创新创业训练计划资助项目
Spectral Analysis and Structural Elucidation of Tenofovir Disoproxil Fumarate
Received date: 2014-10-11
Revised date: 2015-07-21
Online published: 2015-09-05
Supported by
沈阳药科大学大学生创新创业训练计划资助项目
对富马酸替诺福韦二吡呋酯的紫外吸收光谱(UV)、红外吸收光谱(IR)、质谱(ESIMS和HRMS)、核磁共振谱(1H NMR，13C NMR，31P NMR，DEPT-135，COSY，HSQC和HMBC)、差热分析(DSC)和热重分析(TGA)报道并进行解析，对其所有的NMR谱信号进行归属，同时讨论质谱的主要碎片离子的可能的裂解方式和红外特征吸收峰所对应的官能团的振动形式，通过多种谱学技术确证富马酸替诺福韦二吡呋酯的结构．
关键词： 核磁共振(NMR); 归属; 化学位移; 富马酸替诺福韦二吡呋酯; 结构确证
宋爱华1 , 张延峰2 , 沙沂1 , 高源3 , 李宁3 , 马跃平3* . 富马酸替诺福韦二吡呋酯波谱数据与结构确证[J]. 波谱学杂志, 2015 , 32(3) : 542 -550 . DOI: 10.11938/cjmr20150315
Ultraviolet spectrum, infrared spectrum, mass spectra and nuclear magnetic resonance spectra (i.e., 1H NMR, 13C NMR, 31P NMR, DEPT-135, COSY, HSQC and HMBC) of tenofovir disoproxil fumarate were collected and interpreted. All NMR signals were assigned. Based on the mass spectral data, the possible fragmentation pathways were discussed. The infrared spectrum was used to analyze the types of vibration of the functional groups in the compound. The structure of the compound was determined.
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