基于 1H NMR谱的给药赭石大鼠血清代谢组学研究
收稿日期: 2014-12-04
修回日期: 2015-10-23
网络出版日期: 2015-12-05
基金资助
国家自然科学基金资助项目(20975097, 21305134)
A 1H NMR-Based Metabonomic Study on the Serum of Haematitum-Treated Rats
Received date: 2014-12-04
Revised date: 2015-10-23
Online published: 2015-12-05
Supported by
国家自然科学基金资助项目(20975097, 21305134)
魏莹1
,
2
,
章文军1
,
薛蓉2
,
李晓晶2*
,
裴奉奎2
. 基于 1H NMR谱的给药赭石大鼠血清代谢组学研究
[J]. 波谱学杂志, 2015
, 32(4)
: 628
-636
.
DOI: 10.11938/cjmr20150408
Wistar rats were intragastrically administered with different doses (0, 2, 5 g/kg body weight) of haematitum. 1H NMR-based metabonomic techniques were used to analyze the metabolic profiles of the serum samples collected from the treated rats. Significant treatment-related changes were observed for the levels of β-hydroxybutyate, acetate, acetone, choline, glycerophosphorylcholine, glucose, lactate, low density lipoprotein, very low density lipoprotein and lipids. Such biochemical changes indicated that haematitum treatment at the dose of 2 or 5 g/kg body weight gave rise to reactive oxygen species (ROS) and caused peroxidation damage. It is concluded that haematitum treatment affects glucose, lipid and energy metabolism in rats.
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