31P NMR在二异丙基香豆素-3-膦酸酯合成中的应用研究
收稿日期: 2015-08-20
修回日期: 2016-01-22
网络出版日期: 2016-03-05
基金资助
河南省科技厅自然科学基金资助项目(142102210410),河南省教育厅自然科学研究计划资助项目(12A15007, 14B150053);郑州市科技局自然科学基金资助项目(20130883, 131PCXTD605).
Spectroscopy Study on Synthesis of Diisopropyl Coumarin-3-Phosphate by 31P NMR
Received date: 2015-08-20
Revised date: 2016-01-22
Online published: 2016-03-05
通过核磁共振磷谱(31P NMR)对香豆素-3-二异丙基膦酸酯合成的反应过程进行跟踪,讨论了香豆素与亚磷酸二异丙酯在AgNO3催化下的反应机理,并对反应条件进行了优化,对该反应的区域选择性位点进行了分析.
关键词： 核磁共振磷谱(31P NMR); 香豆素-3-二异丙基膦酸酯; 合成
李远哲 , 邱莉 , 尹秋月 , 毛璞 , 肖咏梅 , 屈凌波 , 袁金伟 . 31P NMR在二异丙基香豆素-3-膦酸酯合成中的应用研究[J]. 波谱学杂志, 2016 , 33(1) : 133 -141 . DOI: 10.11938/cjmr20160113
Synthesis of diisopropyl coumarin-3-phosphate was tracked by 31P NMR, and the reaction mechanism was discussed using the materials of coumarin and diisopropyl H-phosphite and AgNO3 as the catalyst. The reaction conditions are optimized, and the regioselectivity of the reaction site is analyzed.
Key words： 31P NMR; diisopropyl coumarin-3-phosphate; synthesis
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