王璐璐 , 朱勇 , 钟凯 . MRI与MRS在肥胖症研究中的应用进展[J]. 波谱学杂志, 2016 , 33(1) : 168 -178 . DOI: 10.11938/cjmr20160116

[1] Westman E, Wahlund LO, Foy C, et al. Combining MRI and MRS to distinguish between Alzheimer's disease and healthycontrols[J]. J Alzheimers Dis, 2010, 22(1): 171－181.

[2] Langkammer C, Ropele S, Pirpamer L, et al. MRI for iron mapping in Alzheimer's disease[J]. Neurodegener Dis, 2014, 13(2, 3): 189－191.

[3] Seppi K. MRI for the differential diagnosis of neurodegenerative parkinsonism in clinical practice[J]. Parkinsonism Relat D, 2007, 13(S3): 400－405.

[4] Choi C B, Kim S Y, Lee S H, et al. Assessment of metabolic changes in the striatum of a rat model of parkinsonism: An in vivo ¹H MRS study[J]. Magn Reson Imaging, 2011, 29(1): 32－39.

[5] Seppi K, Schocke M F. An update on conventional and advanced magnetic resonance imaging techniques in the differential diagnosis of neurodegenerative parkinsonism[J]. Curr Opin Neurol, 2005, 18(4): 370－375.

[6] deBucourt M, Streitparth F, Wonneberger U, et al. Obese patients in an open MRI at 1.0 Tesla: Imagequality, diagnostic impact and feasibility[J]. Eur Radiol, 2011, 21(5): 1 004－1 015.

[7] Brennan D D, Whelan P F, Robinson K, et al. Rapid automated measurementof body fat distribution fromwhole-body MRI[J]. AJR Am J Roentqenol, 2005, 185(2): 418－423.

[8] Fan Ming-xia(范明霞), Tian Jian-ming(田建明), Lu Jian-ping(陆建平), et al. Preliminary evaluation of fatty liver in rats by in vivo ¹H-NMR spectroscopy(活体¹H磁共振波谱分析在大鼠脂肪肝中应用价值的初步研究)[J]. Chin J Med Imaging Technol(中国医学影像技术), 2004, 20(10): 1 503－1 505.

[9] Liu Zhi-jun(刘志军). The development and enlightenment of nuclear magnetic resonance(核磁共振研究的历史)[J]. Journal of Guangxi University for Nationalities(广西民族大学学报), 2011, 17(2): 25－28.

[10] Zhang Yun(张云). The history of nuclear magnetic resonance technology and its application(核磁共振技术的历史及应用)[J]. Science & Technology Information(科技信息), 2010, 15: 116－118.

[11] Lauterbur P C. Image format ion by induced local interactions: Examples employing nuclear magnetic resonance[J]. Nature, 1973, 242: 190－191.

[12] Xian Ru-hong(羡汝珙), Li Yu-huan(李宇寰), Cui Li-ke(崔力科). High field MR imaging and spectroscopy(高场磁共振成像和波谱学)[J]. CT Theory and Applications(CT理论与应用研究), 1994, 3(4): 24－27.

[13] Ni Ping(倪萍), Zhao Ming(赵明), Chen Zi-qian(陈自谦). Developmet and recent progress of MRI magnetic technology (MRI磁体技术的发展历程及展望)[J]. China Medical Equipment(中国医疗设备), 2013, 28(10): 6－10.

[14] Marks S J, Moore N R, Ryley N G, et al. Measurement of liver fat by MRI and its reduction by dexfenfluramine in NIDDM[J]. Int J Obes Relat Metab Disord, 1997, 21(4): 274－279.

[15] Cassidy F H, Yokoo T, Aganovic L, et al. Fatty liver disease: MR imaging techniques for the detection and quantificationof liver steatosis[J]. Radiographics, 2009, 29(1): 231－260.

[16] Ducluzeau P H, Boursier J, Bertrais S, et al. MRI measurement of liver fat content predicts the metabolic syndrome[J]. Diabetes Metab, 2013, 39(4): 314－321.

[17] Kim S, Naik M, Sigmund E, et al. Diffusion-weighted MR imaging of the kidneys and the urinary tract[J]. Magn ResonImaging C, 2008, 16(4): 585－596.

[18] Jin Er-hu(靳二虎), Zhang Jie(张洁), Ma Da-qing(马大庆). MR imaging of anatomical variations and fatty deposit of the pancreas(胰腺解剖变异和脂肪沉积的MRI表现)[J]. Chinese J Magn Reson Imaging(磁共振成像), 2012, 3(3): 213－221.

[19] Zhao Hua-li(赵华丽), Chen Ke-min(陈克敏). Application of MRI breast imaging reporting and data system in breast lesions(MRI乳腺影像报告及数据系统在乳腺疾病诊断中的应用研究)[J]. Journal of Diagnostics Concepts & Practice (诊断学理论与实践), 2011, 10(5): 454－458.

[20] Xiao De-yong(肖德勇). MR Imaging Characteristics and Clinical Pathologic Correlation about Intrapituitary Cystic Degeneration and Fluid-fluid Level Formation(垂体腺瘤囊变及液平面形成的MRI特征与临床病理研究)[D]. Fuzhou(福州): Fujian Medical University(福建医科大学), 2012.

[21] Wu Dao-qing(吴道清), Chen Zi-qian(陈自谦). Evaluation of MR imaging with dynamic contrast-enhancement and diffusion-weighted imaging in diagnosis of prostatic diseases(DCE-MRI与DWI对良恶性前列腺疾病诊断的价值)[J]. Journal of Clinical Radiology(临床放射学杂志), 2010, 29(2): 211－215.

[22] Ni Hong-bin(倪红斌), Liang Wei-bang(梁维邦), Ji Jing(季晶), et al. MRI in patients with cranial nerve disease and find out the neurovascular relationships(MRI在了解颅神经疾病患者血管神经关系上的作用)[J]. Jiangsu Medical Journal(江苏医药), 2005, 31(9): 716.

[23] Andreasen N C. Linking mind and brain in the study of mental illnesses: A project for a scientific psychopathology[J]. Science, 1997, 275(5 306): 1 586－1 593.

[24] Hu H H, Nayak K S, Goran M I. Assessment of abdominal adipose tissue and organ fat content by magnetic resonanceimaging[J]. Obes Rev, 2011, 12(5): e504－515.

[25] Li Jing-jing(李晶晶), Yang Cheng-gang(杨成刚), Zhang Jun(张郡). The application of conventional MR and MR arthrography in the rotator cuff tear(常规MRI及MRI肩关节造影在肩袖撕裂中的应用)[J]. Chinese Imaging Journal of Interated Traditional and Western Medicine(中国中西医结合影像学杂志), 2013, 11(04): 357－358.

[26] Li Zhen-feng(李振峰). Study of 3 T Magnetic Resonance Spectroscory in Patients with Bone and Soft Tissue Tumors(3 T 磁共振波谱在骨与软组织肿瘤中的应用)[D]. Jinan(济南): Shandong University(山东大学), 2007.

[27] Du Xiang-ke(杜湘珂), Feng Yi-lian(冯义廉). Medical MRS is a method of the function of human body metabolic disease examination(医学磁共振波谱是人体功能代谢病生理检查的一种方法)[J]. Chinese J Radiol(中华放射学杂志), 2000, 34(11): 725－726.

[28] He Juan(贺涓). The development status of MRI and MRS evaluation of multiple sclerosis(MRI和MRS评价多发硬化的发展现状)[J]. Foreign Medical Sciences Clinical Radiological Fascicle(国外医学临床放射学分册), 2006, 6: 331－334.

[29] Yang Zhi-hong(杨志宏), Cao Jie(曹杰), Zhang Jia(张佳), et al. Clinical application value of 3.0 T ¹H-MRS in diagnosis of non-alcoholic fatty liver(3.0 T 磁共振¹H-MRS诊断非酒精性脂肪肝的临床应用价值)[J]. Chinese J CT and MRI(中国CT和MRI杂志), 2014, 12(8): 41－43.

[30] Zhao Shuang(赵爽), Li Cai-ying(李彩英), Gao Feng-xiao(高凤宵), et al. The preliminary study of metabolite quantitative of normal livers and hepatic steatosis using 3.0 T ¹H-MRS (3.0 T ¹H-MRS 在正常肝脏与脂肪肝的对照研究)[J]. Journal of Clinical Radiology(临床放射学杂志), 2013, 32(2): 202－206.

[31] Hong Bi-kai(洪璧楷), Dai Hai-yang(代海洋), Xiao Ye-yu(肖叶玉), et al. 9.4 T MR spectroscopy detection of mesenchymal stem cells into osteoblasts metabolism characteristics(9.4 T MR 波谱检测间充质干细胞成骨分化代谢特征的研究)[J]. Chin J Magn Reson Imaging(磁共振成像), 2013, 4(6): 437－440.

[32] Li Feng(李锋), Liu Ke(刘克). The MRI and ¹H-MRS study of primary central nervous system lymphomas(PCNSL)(原发性中枢神经系统淋巴瘤的MRI与¹H-MRS 研究)[J]. J Med Imaging(医学影像学杂志), 2010, 20(9): 1 274－1 277.

[33] Cao Lian-ping(曹连平). A Proton Magnetic Resonance Spectroscopy Study on the Clinical Heterogeneity of Idiopathic Parkinson's Disease(原发性帕金森病临床异质性的¹H-MRS研究)[D]. Fuzhou(福州): Fujian Medical University(福建医科大学), 2013.

[34] Wang Jia(王佳), Fan Guo-guang(范国光). Study of ¹H-MR spectroscopy in the peritumoral area of gliomas(脑胶质瘤周围区的¹H-MRS研究)[J]. Int J Med Radiol(国际医学放射学杂志), 2010, 33(1): 58－62.

[35] Shen Bian-hong(申变红), Li Guo-hai(李国海), Zhang Li-rong(张礼荣), et al. A study on terior cingulate glutamate levels in major depressive patients using proton magnetic resonance spectroscopy(抑郁症患者前扣带回谷氨酸多体素¹H-MRS研究)[J]. J Clin Psychiatry(临床精神医学杂志), 2008, 18(5): 324－326.

[36] Yan You-xia(颜有霞), Liang Chang-hong(梁长虹), Huang Biao(黄飚), et al. MRI and magenetic resonance spectroscopy study of hippocampal sclerosis(海马硬化的MRI及¹H-MRS研究)[J]. Radiol Practice(放射学实践), 2008, 23(1): 17－19.

[37] Yan Min(闫敏), Ou Xiao-qi(欧孝琪). The harm of obesity and its research progress(肥胖症的危害及其研究进展)[J]. Tibetan Journal of Medicine(西藏医药杂志), 2004, 25(3): 27－29.

[38] Galli M M, Protzman N M, Mandelker E M, et al. Comparing tendinous and ligamentous ankle pathology in atraumatic overweight and nonoverweight patients: A comprehensive MRI review[J]. Foot Ankle Spec, 2014, 7(6): 449－456.

[39] Ma Jun(马君), Wang Jun-qin(王菊勤), Han Ying(韩英), et al. New progress in obesity research(肥胖症研究新进展)[J]. Foreign Medical Sciences(国外医学: 护理学分册), 2000, 19(7): 310－311.

[40] Chen Jian-shuang(陈建双), Zhao Lei(赵蕾), Yuan Ya-fei(袁亚非). The progress in obesity research(肥胖症研究进展)[J]. Journal of Chengde Medical College(承德医学院学报), 2007, 24(2): 191－193.

[41] Fabbrini E, Magkos F, Mohammed B S, et al. Intra hepatic fat, not visceral fat, is linked with metabolic complications of obesity[J]. Proc Natl Acad Sci USA, 2009, 106(36): 15 430－15 435.

[42] Rasouli N, Kern P A. Adipocytokines and the metabolic complications of obesity [J]. J Clin Endocrinol Metab, 2008, 93(11): 64－73.

[43] Teede H J, Lombard C, Deeks A A. Obesity, metabolic complications and the menopause: An opportunity for prevention[J]. Climacteric, 2010, 13(3): 203－209.

[44] Artz N S, Haufe W M, Hooker C A, et al. Reproducibility of MR-based liver fat quantification across field strength: same-day comparison between 1.5 T and 3 T in obese subjects[J]. J Magn Reson Imaging, 2015, 42(3): 811－817.

[45] Alderete T L, Toledo-Corral C M, Desai P, et al. Liver fat has a stronger association with risk factors for type 2 diabetes in african-american compared with hispanic adolescents[J]. J Clin Endocrinol Metab, 2013, 98(9): 3 748－3 754.

[46] Zhu An-hui(祝安惠), Cui Bin(崔斌), Yao Dan(姚丹), et al. The correlation of abdominal fat distribution and diabetes mellitus(腹部脂肪分布与糖尿病的相关性研究)[J]. Journal of China Clinic Medical Imaging(中国临床医学影像杂志), 2012, 23(12): 849－852.

[47] Sun Wan-li(孙万里), Chen Liang(陈亮), Zhang Li-hua(张丽华), et al. Mesurement of abdominal adipose tissue by MRI(MRI 测量人腹部脂肪组织)[J]. Radiol Practice(放射学实践), 2007, 22(4): 405－406.

[48] Peng Xin-gui(彭新桂), Ju Sheng-hong(居胜红), Teng Gao-jun(滕皋军). Multiple Genes Rat Adipose Tissue in vivo MRI Chemical Shift Imaging and Spectral Analysis(多种基因鼠脂肪组织的活体MRI化学位移成像及波谱分析)[C]. Zhejiang(浙江): The Chinese Medical Association 16th National Radiology Academic Conference Proceedings(中华医学会第16次全国放射学学术大会论文汇编). 2009.

[49] Qian Jie(钱杰), Zhang Yu-bin(张玉彬). Brown adipose tissue and new targets for obesity treatment(棕色脂肪组织与肥胖症药物治疗的新靶点)[J]. Progress in Pharmaceutical Sciences(药学进展), 2012, 36(11): 487－493.

[50] Liu Gang(刘刚), Huang Yu-shan(黄玉山). The probe into obesity and its endangerment(肥胖及相关问题的认识)[J]. Journal of Shandong Physical Education Institute(山东体育学报), 2001, 51(3): 28－30.

[51] Hu H H, Kim H W, Nayak K S, et al. Comparison of fat-water MRI and single-voxel MRS in the assessment of hepatic and pancreatic fat fractions in humans[J]. Obesity (Silver Spring), 2010, 18(4): 841－847.

[52] Hu Xiao-dong(胡晓东), Li Hong-yan(李鸿炎). Establishment of a mouse model of diet-induced olbesity(饮食诱导小鼠肥胖疾病模型的建立)[J]. Journal of Nanchang University (Medical Science) [南昌大学学报(医学版)], 2012, 52(8): 6－9.

[53] Boggiano M M, Artiga A I, Pritchett C E, et al. High intake of palatable food predicts binge-eating independent of susceptibility to obesity: An animal model of lean vs obese binge-eating and obesity with and without binge-eating[J]. Int J Obes (Lond), 2007, 31(9): 1 357－1 367.

[54] Corwin R L, Wojnicki F H, Fisher J O, et al. Limited access to a dietary fat option affects ingestive behavior but not body composition in male rats[J]. Physiol Behav, 1998, 65(3): 545－553.

[55] Podrini C, Cambridge E L, Lelliott C J, et al. High-fat feeding rapidly induces obesity and lipid derangements in C57BL/6N mice[J]. Mamm Genome, 2013, 24(5, 6): 240－251.

[56] Tian Fang(田方), Jin Hong-xing(金红星), Cheng Wen-yu(成文玉). Construction of mouse nutritional obesity model(小鼠营养性肥胖模型的建立)[J]. Journal of Anhui Agricultural Sciences(安徽农业科学), 2008, 36(36): 15 963－15 964.

[57] Tian Hui(田辉), Wang Yu-ting(王玉婷), Tao Li(陶莉), et al. A new model of obese mice(一种新型小鼠肥胖模型的建立)[J]. Chinese Pharmacological Bulletin(中国药理学通报), 2013, 29(7): 1 016－1 018.

[58] Qian Bo-chu(钱伯初), Shi Hong(史红), Lv Yan-ping(吕燕萍). Progress in studies of preparation of obesity animal models(肥胖动物模型的研究进展)[J]. Chinese Journal of New Drugs(中国新药杂志), 2007, 16(15): 1 159－1 162.

[59] Liu Fang(刘芳). Comparison and Mechanism of Obesity Models Established in Different Strains of Mice & Antiobesity Effects and Mechanism of LRTG(不同品系小鼠肥胖模型比较、肥胖机制研究&LRTG减肥作用及作用机理探讨)[D]. Beijing(北京): Peking Union Medical College Hospital(北京协和医学院), 2013.

[60] Liu Jin-feng(刘金凤), Dong Huan-sheng(董焕生), Pan Qing-jie(潘庆杰), et al. Induction of obesity and insulin resistance in mice using a modified diet(食源性肥胖小鼠胰岛素抵抗模型的建立)[J]. Editorial Dept of Journal of QAU(青岛农业大学学报: 自然科学版), 2014, 31(2): 91－94.

[61] Wang Shu-ran(王舒然), Ma Wei-wei(麻微微), Zhao Dan(赵丹), et al. Establishment of obesity prone and obesity resistant rats induced by high-fat diet(高脂饮食诱导肥胖与肥胖抵抗动物模型建立)[J]. Chinese Journal Public Health(中国公共卫生), 2007, 23(07): 774－775.

[62] Machann J, Horstmann A, Born M, et al. Diagnostic imaging in obesity[J]. Best Pract Res Cl En, 2013, 27(2): 261－277.

[63] Ducluzeau PH, Boursier J, Bertrais S, et al. MRI measurement of liver fat content predicts the metabolic syndrome[J]. Diabetes Metab, 2013, 39(4): 314－321.

[64] Lunati E, Marzola P, Nicolato E, et al. In vivo quantitative hydrolipidic map of perirenal adipose tissue by chemical shiftimaging at 4.7 tesla[J]. J Lipid Res, 1999, 40(8): 1 395－1 400.

[65] Liu Yu-bao(刘于宝), Liang Chang-hong(梁长虹). The progress of qualitative and quantitative research in fatty liver withMRI(MRI 定性定量研究脂肪肝的进展)[J]. Journal of Clinical Radiology(临床放射学杂志), 2006, 25(10): 975－978.

[66] Li Shao-rui(李少蕊), Weng De-he(翁得河), Chen Hui-cheng(陈会城). A water-fat separation magnetic resonance imagemethod based on inversion recovery(基于反转恢复技术的水脂分离磁共振成像方法)[J]. Chinese J Magn Reson(波谱学杂志), 2012, 29(4): 547－553.

[67] Peng Xin-gui(彭新桂), Ju Sheng-hong(居胜红), Teng Gao-jun(滕皋军). (MR活体脂肪成像和波谱分析)[J]. Chin J Radiol(中华放射学杂志), 2009, 43(8): 894－897.

[68] Bao J, Cui X, Cai S, et al. Brown adipose tissue mapping in rats with combined intermolecular double-quantum coherenceand Dixon water-fat MRI[J]. NMR Biomed, 2013, 26(12): 1 663－1 671.

[69] Wang Xiao-hong(王小红), Zhang Qin-ta(张钦塔), Lin Yan-qin(林雁勤), et al. Two-dimensional localized magnetic resonance spectroscopy and its in vivo application(二维核磁共振定域谱及其在活体中的应用)[J]. Chinese J Magn Reson(波谱学杂志), 2011, 28(3): 419－436.

[70] Wattjes M P, Kley R A, Fischer D. Neuromuscular imaging in inherited muscle diseases[J]. Eur Radiol, 2010, 20(10): 2 447－2 460.

[71] Lee Y, Lingvay I, Szczepaniak L S, et al. Pancreatic steatosis: Harbinger of type 2 diabetes in obese rodents[J]. Int J Obes(Lond), 2010, 34(2): 396－400.

[72] Reeder S B, Cruite I, Hamilton G, et al. Quantitative assessment of liver fat with magnetic resonance imaging andspectroscopy[J]. J Magn Reson Imaging, 2011, 34(4): 729－749.

[73] Tian Bing(田冰), Huang Wen-cai(黄文才), Lu Jian-ping(陆建平). Application of proton magnetic resonance spectroscopy in somatic organs(体部器官¹H-MRS的应用)[J]. Chin J Med Imaging Technol(中国医学影像技术), 2011, 27(5): 1 082－1 085.

[74] Peng Xin-gui(彭新桂), Bai Ying-ying(柏盈盈), Ju Sheng-hong(居胜红). In vivo detection of fat quantitative and studyusing ¹H-MRS in ob/ob and WT mice (ob/ob与野生型小鼠脂肪组织的磁共振波谱研究)[J]. J Southeast Univ(东南大学学报), 2014, 33(3): 260－266.

[75] Lê KA, Faeh D, Stettler R, et al. A 4-wk high-fructose diet alters lipid metabolism without affecting insulin sensitivity orectopic lipids in healthy humans[J]. Am J Clin Nutr, 2006, 84(6): 1 374－1 379.

[76] Lee S J, Boesch C, Kuk J L, et al. Effects of an overnight intravenous lipid infusion on intramyocellular lipid content andinsulin sensitivity in African American versus Caucasian adolescents[J]. Metabolism, 2013, 62(3): 417－423.