1H NMR STUDY ON THE STEREOCHEMISTRY OF 1,3-OXAZINO[3,2-D] [1,5] BENZODIAZEPINE-1-ONES

Chinese Journal of Magnetic Resonance ›› 2000, Vol. 17 ›› Issue (5): 362-367.

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¹H NMR STUDY ON THE STEREOCHEMISTRY OF 1,3-OXAZINO[3,2-D] [1,5] BENZODIAZEPINE-1-ONES

XU Hao², XU Jia-xi², LIU Xue-hui¹, JIN Sheng², CUI Yu-xin¹

1. National Laboratory of Natural, Biomimetic Drugs, Medical, Healthy Analysis Center, Peking University, Beijing 100083;
2. College of Chemistry, Molecular Engineering, Peking University, Beijing 100871

Received:2000-06-19 Revised:2000-07-24 Published:2000-10-05 Online:2018-01-11

Abstract

Abstract: A series of 1,3-oxazino[3,2-d] [1,5] benzodiazepine-1-one derivatives' stereochemistry was studied by ¹H NMR. During the ¹H NMR experiments, we found out their unique stereochemistry of seven-membered rings. All the discernible hydrogen's chemical shifts were assigned. Their distorted boat conformations were discovered by the related coupling constants and gNOESY results, which were compared with x-ray diffraction result and the conformation of analogous benzothioazepines.

Key words: Benzodiazepine, Stereochemistry, ¹H NMR

CLC Number:

O641.13

XU Hao, XU Jia-xi, LIU Xue-hui, JIN Sheng, CUI Yu-xin. ¹H NMR STUDY ON THE STEREOCHEMISTRY OF 1,3-OXAZINO[3,2-D] [1,5] BENZODIAZEPINE-1-ONES[J]. Chinese Journal of Magnetic Resonance, 2000, 17(5): 362-367.

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¹H NMR STUDY ON THE STEREOCHEMISTRY OF 1,3-OXAZINO[3,2-D] [1,5] BENZODIAZEPINE-1-ONES

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