IN VIVO STUDIES OF TAXOL CHEMOTHERAPY IN A MOUSE S180 SARCOMA BY 31P MAGNETIC RESONANCE SPECTROSCOPY

Chinese Journal of Magnetic Resonance ›› 1999, Vol. 16 ›› Issue (1): 7-12.

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IN VIVO STUDIES OF TAXOL CHEMOTHERAPY IN A MOUSE S180 SARCOMA BY ³¹P MAGNETIC RESONANCE SPECTROSCOPY

Tian Jianguang¹, Wei Changhua², Feng Rui¹, Li Guangyu¹, Ru Xiangbin², Du Zehan¹

1. National Center for Biomedical Analysis, Academy of Military Sciences, Beijing 100850;
2. Institute of Pharmacology and Toxicology, Academy of Military Sciences, Beijing 100850

Received:1998-11-16 Revised:1998-12-07 Published:1999-02-05 Online:2018-01-11

Abstract

Abstract: Objective:To study whether the changes of ³¹P MRS parameters of mouse S180 sarcoma treated by Taxol is earlier than the changes of tumor volume. Methods:Mouse S180 sarcoma (i.p.) was studied by using surface-coil ³¹P NMR. Results:After 48h following treatment, PCr/Pi and β-NTP/Pi ratios of treated groups are higher than those of control group (P <0.05), PME/β-NTP ratio of treated groups is lower than that of control group (P <0.05). The tumor volume between treated groups and control group showed no significant difference. Conclusion:³¹P MRS of mouse S180 sarcoma can offer not only quantitative information, but show also earlier response to therapy.

Key words: Taxol, Mouse S180 sarcoma, Surface coil, ³¹P MRS

Tian Jianguang, Wei Changhua, Feng Rui, Li Guangyu, Ru Xiangbin, Du Zehan. IN VIVO STUDIES OF TAXOL CHEMOTHERAPY IN A MOUSE S180 SARCOMA BY ³¹P MAGNETIC RESONANCE SPECTROSCOPY[J]. Chinese Journal of Magnetic Resonance, 1999, 16(1): 7-12.

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IN VIVO STUDIES OF TAXOL CHEMOTHERAPY IN A MOUSE S180 SARCOMA BY ³¹P MAGNETIC RESONANCE SPECTROSCOPY

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