Chinese Journal of Magnetic Resonance ›› 1999, Vol. 16 ›› Issue (3): 219-224.

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STUDY ON THE SYNTHESIS AND ABSOLUTE CONFIGURATIONS OF GRIGNARD ADDITION PRODUCTS OF FURANOSES BY 2D NMR

Zhang Minglong, Cui Yuxin, Liu Xuehui, Li Jingguang, Ma Lingtai, Zhang Lihe   

  1. The National Laboratory of Natural and Biomimetic Drugs, School of Pharmaceutical Sciences, Beijing Medical University, Beijing 100083
  • Received:1999-01-25 Revised:1999-03-15 Published:1999-06-05 Online:2018-01-11
  • Supported by:
    Supported by National Natural Science Foundation of China

Abstract: Phenyl and benzyl furanoses have been prepared stereoselectively by Grignard nucleophilic addition to their correspondent furanoses. Their structures and absolute configurations were studied and described by measuring the two-dimensional NMR spectroscopy. The results have been compared and confirmed by computational optimizing model data.

Key words: Grignard nucleophilic addition, Absolute configuration, 2D NMR spectroscopy, Computational optimizing