ESR STUDY ON FREE RADICAL GENERATION AND SCAVENGING IN VIVO DURING MYOCARDIAL ISCHEMIA AND REPERFUSION

Chinese Journal of Magnetic Resonance ›› 1996, Vol. 13 ›› Issue (4): 341-346.

ESR STUDY ON FREE RADICAL GENERATION AND SCAVENGING IN VIVO DURING MYOCARDIAL ISCHEMIA AND REPERFUSION

Zhan Ruiyun¹, Xu Jie¹, LiU GuiZhen¹, Zhu Yanshi¹, Zhao Dan², Li Yang², Zhang Jian², Zhao Xuejian², Zhou Zhengzhi³, Liu Zhongrong³

1. Changchun Institute of Applied Chemistry, Chinese Academy of Sciences, Changchun 130022;
2. Depantment of Pathophysiology, Norman Bethune University of Medical Scien, Changchun 130021;
2. Chengdu Institute of Biology, Chinese Academy of Sciences, Chengdu 610041

Received:1995-09-26 Published:1996-08-05 Online:2018-01-17

Abstract

Abstract: ESR and spin trapping technique were used to study radical generation in living animal dogs during the course of myocardial ischemia and reperfusion.ESR analysis showed that the species trapped by PBN from coronary veinous blood is OH radical,which provided directly an evidence supporting the active oxygen radicals hypothesis of ischemia-reperfusion cell damage.Further experiment had found that a kind of saponin drug is an effective scavenger and has a capability for protecting myocardial cell membrane on radical damage.

Key words: Dog, Myocardial ischemia and reperfusion, Radical, ESR

Zhan Ruiyun, Xu Jie, LiU GuiZhen, Zhu Yanshi, Zhao Dan, Li Yang, Zhang Jian, Zhao Xuejian, Zhou Zhengzhi, Liu Zhongrong. ESR STUDY ON FREE RADICAL GENERATION AND SCAVENGING IN VIVO DURING MYOCARDIAL ISCHEMIA AND REPERFUSION[J]. Chinese Journal of Magnetic Resonance, 1996, 13(4): 341-346.

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ESR STUDY ON FREE RADICAL GENERATION AND SCAVENGING IN VIVO DURING MYOCARDIAL ISCHEMIA AND REPERFUSION

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