STUDIES ON HMQC AND HMBC SPECTRA OF A HYPOTENSIVE COMPOUND ICARIIN

Chinese Journal of Magnetic Resonance ›› 1996, Vol. 13 ›› Issue (6): 595-600.

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STUDIES ON HMQC AND HMBC SPECTRA OF A HYPOTENSIVE COMPOUND ICARIIN

Kong Lingyi¹, Li Yi², He Aimin³, Min Zhida¹

1. Department of Natural Medicinal Chemistry, China Pharmaceutical University, Nanjing 210009;
2. Central Laboratory of Chemistry and Physics, Nanjing University, Nenjing 210097;
3. Department of Natural Medicinal Chemistry, Shanghai 200032

Received:1996-05-19 Revised:1996-07-22 Published:1996-12-05 Online:2018-01-17

Abstract

Abstract: The HMQC and HMBC spectra of icariin,a natural flavonoid isolated from theaerial parts of Epimedium grandiflorum,whid showh evident hypotensive action,were studied for the first time.The signals of protons in ¹H NMR and carbons in ¹³C NMR of the Compound were assigned definitely.Some mistakes about assignments of carbon signals were revised by 2D NMR.The attached positions of methoxy,isoprene,rhamnose and glucose in the molecule of the compound were directly confirmed according to the correlated cross peaks in HMBC spectrum.The results of the paper indicate that HMQC and HMBC spectra exert significance on structural elucidation of new natural microcompounds.

Key words: Icariin, HMQC, HMBC, Attached Positions

Kong Lingyi, Li Yi, He Aimin, Min Zhida. STUDIES ON HMQC AND HMBC SPECTRA OF A HYPOTENSIVE COMPOUND ICARIIN[J]. Chinese Journal of Magnetic Resonance, 1996, 13(6): 595-600.

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STUDIES ON HMQC AND HMBC SPECTRA OF A HYPOTENSIVE COMPOUND ICARIIN

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