Chinese Journal of Magnetic Resonance ›› 1998, Vol. 15 ›› Issue (6): 521-526.

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STUDIESOF 31P MRSOF MOUSE BRAIN DURING ACUTE ISCHEMIA

Tian Jianguang, Du Zehan, Feng Rui, Li Guangyu   

  1. National Center for Biomedical Analysis, Beijing 100850
  • Received:1998-05-08 Revised:1998-06-19 Published:1998-12-05 Online:2018-01-17

Abstract: The characteristics of energy metabolism of mouse brain during acute ischemia was studied using 31P NMR.After the ligation of two-sided common carotid artery along with vagus, PCr/Pi、β-ATP/Pi ratios decreased dramatically,and PCr/Pi ratio decreased faster,at the same time brain cells suffered acidosis.Reperfusion after 5min ischemia can partly reverse the injury caused by ischemia.

Key words: Mouse brain, Acute ischemia, 31P MRS