Chinese Journal of Magnetic Resonance ›› 1988, Vol. 5 ›› Issue (2): 123-128.

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DETERMINATION OF CONFIGURATION OF MORPHINE AND CODEINE BY ONE AND TWO-DIMENSIONAL NMR

Wang Dehua1, George C. Levy2   

  1. 1. Laboraiory of Magnetic Resonance and Atomic and Molecular Physics, Wuhan Institute of Physics, Wuhan;
    2. Department of Chemistry, Syracuse University, USA
  • Received:1987-06-04 Revised:1987-09-03 Published:1988-06-05 Online:2018-01-22

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Abstract: Coupling constants of morphine and codeine were obtained by using 360 MHz NMR. The coupling patterns were verified by a J-resolvcd two-dimensional spectrum. The dihedral angles were calculated by using a series of modified Kar-plus equations.The configurations of morphine and codeine were calculated from X-ray bond length and the calculated dihedral angles.

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