Chinese Journal of Magnetic Resonance ›› 1989, Vol. 6 ›› Issue (2): 163-168.

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SOLUTION CONFORMATION OF TETRANDRINE

Pan Jingxian1, Zhao Jicang1, Han Guiqiu1, B. Arison2, Y. K. Lam2, P. Rinald2   

  1. 1. School of Pharmaceutical Sciences, Beijing Medical University;
    2. Merck Sharp & Dohme Research Laboratories
  • Received:1988-03-08 Revised:1988-04-18 Published:1989-06-05 Online:2018-01-22

Abstract: Solution conformation of tetrandrine was studied by NMR 1H NOESY and 1H-13C HETCOR. The success in interpreting all NMR observations in terms of the x-ray crystal diagram is compelling evidence that the solution and solid state conformations are essentially the same.

Key words: Tetrandrine, 1H NOESY, 1H-13C HETCOR, Solution Conformation