Abstract: Temporal lobe structures are involved in various neurodegenerative diseases. In this study, metabolic profiles in the temporal lobes (TL), hippocampus (HPC) and entorhinal cortex (EC) of SD rats were measured by highresolution magic-angle-spinning (HR-MAS) ¹H NMR spectroscopy. Principal components analysis (PCA) was used to classify the HR-MAS ¹H NMR spectra obtained from different brain regions. It was found that TL has relatively low concentrations of myo-inositol and total creatine and relatively high concentrations of N-acetylaspartate and taurine, while HPC has relatively high levels of glycine and choline compounds, and EC has a high level of glutamine. HR-MAS ¹H NMR spectroscopy may provide a valuable tool for monitoring metabolic changes in the temporal lobe structures related to neurodegenerative diseases and pharmacological challenges.

Key words: HR-MAS NMR, metabolic profiles, principal component analysis, S.D. rat, temporal lobe