Chinese Journal of Magnetic Resonance ›› 2006, Vol. 23 ›› Issue (1): 89-94.

• Articles • Previous Articles     Next Articles

Inclusion Complexes of Nitroxide Radicals with β-Cyclodextrin and 2- Hydroxypropyl β-Cyclodextrin in Aqueous Solution Studied  by EPR Spectroscopy

  

  1. Gansu College of Traditional Chinese Medicine, Lanzhou, Gansu 730000,  China
  • Received:2005-06-22 Revised:2005-09-05 Published:2006-03-05 Online:2006-03-05

Abstract:

It was found in this study that the ESR spectra of three nitroxide radicals, 4-hydroxy-2,2,6,6-tetramethyliperidine-1-oxyl (R1), 4-azido-2,2,6,6-tetramethyliperdine-1-oxyl (R2) and 4-oxybenzene-sulfonyl-2,2,6,6-tetramethyliperidene-1-oxyl (R3), show distinctive changes in rotational correlation time τC and hyperfine splitting constants aN when included in β-cyclodextrin (β-CD) and 2-hydroxypropyl-β-CD in aqueous solution. Based on the EPR results, it is suggested that the steric factors and polarity of the functional groups affect the inclusion reaction.

Key words: EPR, inclusion complexes, cyclodextrin, nitroxide radical

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