ON PROPERTIES OF EVENT-RELATED fMRI BOLD RESPONSE IN PRIMARY VISUAL CORTEX OF HUMAN BRAIN DURING VISUAL STIMULATION

Chinese Journal of Magnetic Resonance

ON PROPERTIES OF EVENT-RELATED fMRI BOLD RESPONSE IN PRIMARY VISUAL CORTEX OF HUMAN BRAIN DURING VISUAL STIMULATION

WU Yi-gen1, TIAN Zhi-xiong2, HUANG Xiong2, WU Guang-yao2, LI Li-yun3, SUN Jun-mo2, LIU Mai-li3, TANG Xiao-wei1, 4*

1.Institute of High Energy Physics and Laboratory of Nuclear Analysis Techniques，The Chinese Academy of Sciences，P.O. Box 918，Beijing 100039, China;
2.Zhongnan Hospital，Wuhan University，Wuhan 430071, China;
3.State Key Laboratory of Magnetic Resonance and Atomic and Molecular Physics，Wuhan Institute of Physics and Mathematics, The Chinese Academy of Sciences，Wuhan 430071, China; 4.Department of Physics, Zhejiang University, Hangzhou 310027, China

Received:2002-12-20 Revised:2003-03-20 Published:2003-09-05 Online:2003-09-05
About author:*Correspondence author:Tang Xiao-wei,E-mail:tangxw@zju.edu.cn
Supported by:
国家重点基础研究规划“脑功能和脑重大疾病的基础研究”资助项目（1999054006）.

Abstract

Abstract:

Functional magnetic resonance imaging (fMRI) using the blood oxygenation level dependent (BOLD) contrast is an important noninvasive method to study
the functional activities of the brain. Many fMRI studies, especially the experimental studies，have focused on the mechanisms of the BOLD effect and its relationship with brain functions. Properties of fMRI BOLD response in the primary visual cortex of human brain during visual stimulation have been investigated previously，however the results obtained have been contradictory in terms of whether there is a linear relationship between the response and the stimulus. In this study, we applied event-related fMRI to study the BOLD response in human primary visual cortex to the short visual stimuli with durations of 1、2、3、4、5 and 6 seconds respetively. The results show that generally there is a linear relationship between the BOLD response and the duration of the stimulus.

Key words: event-related fMRI, BOLD, visual stimulation, brain activation map, linear relationship

CLC Number:

O482.53

WU Yi-gen1, TIAN Zhi-xiong2, HUANG Xiong2, WU Guang-yao2, LI Li-yun3, SUN Jun-mo2, LIU Mai-li3, TANG Xiao-wei1, 4*. ON PROPERTIES OF EVENT-RELATED fMRI BOLD RESPONSE IN PRIMARY VISUAL CORTEX OF HUMAN BRAIN DURING VISUAL STIMULATION[J]. Chinese Journal of Magnetic Resonance.

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