2D heteronuclear NMR experiments are very useful tools for determining the structure of small or medium molecules. Especially, the heteronuclear long
-range experiments from ¹H to ¹³C or ¹⁵N  are the most powerful implements to allow chemist the bridging of isolated fragments molecules and allow placement of quaternary ¹³C (or ¹⁵N) atoms. However, the resolution in the dimension of the heteroatom of indirect detection experiments can not meet the requirement of resonance assignment. Linear prediction, band-selection, and careful aliasing are three different strategies to achieve higher resolution. Recently a new approach has been advanced by utilizing Hadamard Excitation Sculpting. The high rf quality and flexibility of VNMR software tools allow users of Varian NMR systems to easily adopt novel excitation sculpting schemes to dramatically increase in gHMBC experiments.