1H-MRS STUDY OF THE METABOLITE ON THE BORDER ZONE OF ACUTE CEREBRAL ISCHEMIA

Chinese Journal of Magnetic Resonance

¹H-MRS STUDY OF THE METABOLITE ON THE BORDER ZONE OF ACUTE CEREBRAL ISCHEMIA

YI Li1,2, LU Guang1, LIU Mai-li1, ZHANG Su-ming2

1.State Key Laboratory of Magnetic Resonance and Atomic and Molecular Physics, Wuhan Institute of Physics and Mathematics, The Chinese Academy of Sciences, Wuhan 430071, China;
2.Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan 430030, China

Received:2001-07-11 Revised:2001-11-15 Published:2002-03-05 Online:2002-03-05
Supported by:
国家自然科学基金重点资助项目（39730170）；国家自然科学基金资助项目（39770810）；国家自然科学基金资助项目（30070825）.

Abstract

Abstract:

Objective The use of different models of focal cerebral ischemia to appraise the time-space rules of ¹H-MRS on measuring metabolism and energy changes in the post-ischemia brain tissue provides the clinical doctors with valuable informati on to judge the prognosis and carry out more effective therapy from the biochemi cal point of view. Methods 9 healthy Sprague-Dawly rats(indiscrimi nate the sex) was divided into two groups randomly. Group A (4 rats), occluded with self-thrombus for 1 h; Group B (5 rats), occluded with thread-emboli fo r 1 h. The ¹H-MRS was examined in 30, 40, 50, 60 min after occlusion respectively, and the metabolic changes of NAA, C ho and Lac in the reg ions of interest in partly-fixed quantity were analyzed. Results Set the resonance intregrated area ratio of NAA, Cho, Lac to Pcr+Cr as the criterion, the values of a ll the metabolites declined gradually within 1 h after ischemia. Especially, the ratio of Cho/（Pcr+Cr）、NAA/（Pcr+Cr）and Lac/（Pcr+Cr）in 60 min has significant difference from that in 50 min (P<0.05). Conclusions Magnetic Reson ance Proton Spectroscopy is a good research tool, which is straightforward, comp rehe nsive and no damage, for the study of cellular metabolism and the status of the biochemical energy in acute ischemia stroke.

Key words: magnetic resonance proton spectroscopy, ischemia

CLC Number:

R816.1

YI Li1,2, LU Guang1, LIU Mai-li1, ZHANG Su-ming2. ¹H-MRS STUDY OF THE METABOLITE ON THE BORDER ZONE OF ACUTE CEREBRAL ISCHEMIA[J]. Chinese Journal of Magnetic Resonance.

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¹H-MRS STUDY OF THE METABOLITE ON THE BORDER ZONE OF ACUTE CEREBRAL ISCHEMIA

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