Chinese Journal of Magnetic Resonance

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THE STUDY OF SYNTHESIZING CLINDAMYCIN PHOSPHATE BY 31P NMR

LIU Hong-min, ZHU Wei-guo, LIU Zhen-zhong, LI Xiao-qiang, KANG Jian-xun   

  1. Chemistry Department,  Zhengzhou University,  Zhengzhou 450052, China
  • Received:2001-08-06 Revised:2001-12-17 Published:2002-06-05 Online:2002-06-05
  • Supported by:

    河南省自然科学基金资助项目(004032000).

Abstract:

In this paper the process of synthesizing clindamycin has been observed by 31P NMR, especially, the hydrolyzing reaction form of clindamycin phosphate chl oride  was investigated. And some reaction mechanism has been discussed. The rational reaction condition was obtained by the study.

Key words: 31P NMR, clindamycin, synthesis

CLC Number: