Chinese Journal of Magnetic Resonance

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METHODS TO DETERMINE THE ABSOLUTE STEREOCHEMISTRY OF ORGANIC COMPOUNDS BY NMR SPECTROSCOPY

TENG Rong-wei1, SHEN Ping2, WANG De-zu1, YANG Chong-ren1*   

  1. 1.Kunming Institute of Botany,  Chinese Academy of Sciences,  Kunming  650204, China; 
    2.Laboratory of Pyhtochemistry,  Shenyan College of Pharmacology,  Shenyang  110016, China
  • Received:2001-08-06 Revised:2001-10-15 Published:2002-06-05 Online:2002-06-05
  • About author:*Correspondence author

Abstract:

This paper reviews the NMR methods to determine the absolute stereoche mistry of organic compounds.The methods are classified into two types in terms o f the principle in this paper. One applies magnetic anisotropy effect of phenyl orother aryl groups, such as Mosher method, methods utilizing MPA or other AM As chiral reagents. The other type applies glycosylation shift effects due to glyco sylate reactions, such as tetra-O-benzoyl glucosylation method and fucofurano side method. This review deals with the principle,  the determining process, the advantages and disadvantages of each mothod.

Key words: organic compounds, absolute stereochemistry, NMR spe ctroscopy

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