THE APPLICATION OF FUNCTIONAL MAGNETIC REGSONANCE IMAGING IN PSYCHIATRIC DISEASES

Abstract

Abstract:

Magnetic Resonance Imaging(MRI) of the brain is well-recognized for its excellent spatial resolution, allowing neuroantomic structures to be viewed in sharp detail. Recently, it has become possible to modify a conventional MRI scanner to study the brain's function as well. This new technique, called functional Magnetic Resonance Imaging (fMRI), has excited brain-researchers for its several good features. The most commonly used fMRI technique is BOLDfMRI (

Blood-Oxygen-Level-Dependent-fMRI). It is based on the principle that when abrain region is being used, arterial oxygenated blood will redistribute and increase to this area. Perfusion fMRI which can measure absolute regional blood flow has some limitations in that it takes several minutes to acquire information on a single slice of interest. It would be tedious obtainto enough images on this slice within a single session to make a statistical statement on a given subject. Diffusion-weight Imaging is used to diagnosis the early post-storke and to detecte the direction of myelin fibers tracts. MRI spectroscopy, an old fMRI technique, offers the capability of using MRI to noninvasively study tissue biochemistry which can determine the level of substance or energy metabolism. These techniques have been used widespreadly in neurology and neurosurgery. While there are currently no clinical indications for ordering any of these fMRI techniques, they hold considerable promise for unraveling the neurocircuitry and metabolic pathways of psychiatric disorders in the immediate future and in helping in psychiatric diagnosis and treatment planning down the road.

Key words:

Functional Magnetic Resonance Imaging, BOLD effect, Psychiatric disease, Brain function

CLC Number:

O482.53++2

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