A T1 magnetic resonance imaging (MRI) contrast agent specific to lung cancer stem cells Gd-DOTA-HCBP-1 was synthesized by solid-phase peptide synthesis technology. Its longitudinal relaxation rate (r1) was 6.15 mmol-1·L·s-1, approximately 0.6 times higher than that of the commercial T1 contrast agents Dotarem at 11.7 T. In vitro MRI experiments indicated that the detectability of the cancer stem cells could be significantly improved to about 2 000~4 000 cells per sphere by the use of the probe.
LI Chun-lin
,
YING Xiao-fang
,
WEI Jian-dong
,
ZHANG Hai-lu
,
ZHANG Hong-yan
,
DENG Zong-wu
,
ZHU Yi-min
,
TAN Bo
. A Gadolinium-Based T1 MRI Probe for Detection of Lung Cancer Stem Cells[J]. Chinese Journal of Magnetic Resonance, 2016
, 33(4)
: 627
-634
.
DOI: 10.11938/cjmr20160412
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