Abnormal metabolism γ-aminobutyric acid (GABA) is involved in many brain diseases, and in vivo GABA detection is important for the diagnosis of these diseases. This study optimized a commonly used spectral editing method for in vivo GABA detection, MEGA-PRESS. We used high-performance Shinnar-Le Roux (SLR) pulses to replace the commonly used Gaussian pulses. Single-band pulse and dual-band pulse were combined to excite the resonances of given metabolites. An optimized MEGA-PRESS sequence was implemented on the uMR780 magnetic resonance imaging system manufactured by United Imaging Healthcare (UIH). The results showed that the SLR pulse could reduce the interference of macromolecule (MM) on GABA signal. Compared with the traditional methods, combining the single-band and dual-band pulses could better suppress contamination of residual water signal to the GABA* signal. Volunteer experiments demonstrated that the optimized MEGA-PRESS sequence improved in vivo measurement of GABA* concentration.
HUA Rui
,
SUN Yu
,
WEN Lin-fei
,
LIU Hui
,
WAN Sui-ren
. Optimization of the MEGA-PRESS Sequence for Detection of γ-Aminobutyric Acid in Vivo[J]. Chinese Journal of Magnetic Resonance, 2018
, 35(2)
: 188
-197
.
DOI: 10.11938/cjmr20172601
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