Articles

A Novel Molecular Cage for Hyperpolarized 129Xe Based on Cucurbit[6]uril Nanoparticles

  • YUAN Chen-lu ,
  • GUO Qian-ni ,
  • CHEN Shi-zhen ,
  • ZHOU Xin
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  • 1. State Key Laboratory of Magnetic Resonance and Atomic and Molecular Physics, National Center for Magnetic Resonance in Wuhan(Wuhan Institute of Physics and Mathematics, Chinese Academy of Sciences), Wuhan 430071, China;
    2. University of Chinese Academy of Sciences, Beijing 100049

Received date: 2019-04-26

  Online published: 2019-05-30

Abstract

Hyperpolarized 129Xe NMR has a detection sensitivity up to 10 000 times higher than that in the conventional 1H NMR. Hyperpolarized 129Xe gas has only one NMR signal, but can produce multiple signals when combined with molecular cages, providing the chances to develop targeted molecular probes. In this paper, water-soluble cucurbit[6]uril nanoparticles were used for loading hyperpolarized 129Xe gas to construct targeted molecular probes. It was observed that such molecular probes had double "cage" signals and the potential to be developed into multi-functional probes.

Cite this article

YUAN Chen-lu , GUO Qian-ni , CHEN Shi-zhen , ZHOU Xin . A Novel Molecular Cage for Hyperpolarized 129Xe Based on Cucurbit[6]uril Nanoparticles[J]. Chinese Journal of Magnetic Resonance, 2019 , 36(4) : 472 -480 . DOI: 10.11938/cjmr20192742

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