Chinese Journal of Magnetic Resonance >
A Study on the Alteration of Spontaneous Brain Activity in Somatic Symptoms Disorder Combining Regional Homogeneity and Amplitude of Low-frequency Fluctuation
Received date: 2021-03-01
Online published: 2021-06-02
Somatic symptom disorder (SSD) is a common medical disorder characterized by various biological, psychological, and social pathogenic factors. At present, little is known about the neural mechanism of SSD. This study evaluated the dysfunction in 45 patients with SSD and 43 controls by combining the amplitudes of low-frequency fluctuation (ALFF) and regional homogeneity (ReHo) methods with resting-state functional magnetic resonance imaging (fMRI). The patients with SSD exhibited significantly greater ReHo values in the right middle cingulate gyrus, and smaller ReHo values in the right precuneus, the left inferior temporal gyrus extending to the left middle temporal gyrus and the left parahippocampal gyrus, and the right pons compared with the controls. The SSD patients showed higher ALFF values in the middle cingulate gyrus extending to the left middle frontal gyrus, the right insula extending to the right inferior frontal gyrus, and left middle frontal gyrus extending to the left anterior cingulate cortex. These dysfunction areas are involved in self-relevant processes, emotional processing, and body perception, which are closely related to the pathogenesis of SSD.
Yang-yang CUI , Huai-bin LIANG , Qian ZHU , Wei TANG , Ting-ting GAO , Jian-ren LIU , Xiao-xia DU . A Study on the Alteration of Spontaneous Brain Activity in Somatic Symptoms Disorder Combining Regional Homogeneity and Amplitude of Low-frequency Fluctuation[J]. Chinese Journal of Magnetic Resonance, 2022 , 39(1) : 64 -71 . DOI: 10.11938/cjmr20212894
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