Chinese Journal of Magnetic Resonance >

2024 , Vol. 41 >Issue 4: 363 - 372

DOI: https://doi.org/10.11938/cjmr20243106

Articles

Assessment of Pulmonary Function Changes of AECOPD with Hyperpolarized 129Xe MR

  • LI Lianjie ,
  • ZHENG Yu ,
  • XIE Shuguang ,
  • ZHANG Ming ,
  • LI Hongchuang ,
  • LIU Xiaoling ,
  • ZHAO Xiuchao ,
  • HAN Yeqing ,
  • LI Haidong ,
  • FAN Li ,
  • XIAO Yi ,
  • LIU Shiyuan ,
  • ZHOU Xin
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  • 1. University of Shanghai for Science and Technology, Shanghai 200093, China
    2. State Key Laboratory of Spectroscopy and Atomic and Molecular Physics, Wuhan Center for Magnetic Resonance, Innovation Academy for Precision Measurement Science and Technology, Wuhan 430071, China
    3. Huazhong University of Science and Technology, Wuhan 430074, China
    4. Department of Radiology, Second Affiliated Hospital of Naval Medical University, Shanghai 200003, China
    5. University of Chinese Academy of Sciences, Beijing 100049, China
    6. School of Medical Imaging, Xuzhou Medical University, Xuzhou 221000, China

Received date: 2024-03-28

  Online published: 2024-04-13

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Abstract

The acute exacerbation of chronic obstructive pulmonary disease (AECOPD) constitutes a significant adverse event in the trajectory of COPD. In this study, we utilized hyperpolarized 129Xe magnetic resonance (MR) to explore the alterations in alveolar microstructure and pulmonary gas exchange function in an AECOPD disease model. Our findings revealed that, in comparison to the emphysema group, the microstructure remained relatively unchanged in the acute exacerbation group, while gas exchange function exhibited a decrease. Notably, these observed changes correlated well with histological findings and pulmonary function assessments, indicating the feasibility and sensitivity of hyperpolarized 129Xe MR in detecting AECOPD.

Key words： hyperpolarized 129Xe MR; DWI; CSSR; COPD; emphysema; acute exacerbation

Cite this article

LI Lianjie , ZHENG Yu , XIE Shuguang , ZHANG Ming , LI Hongchuang , LIU Xiaoling , ZHAO Xiuchao , HAN Yeqing , LI Haidong , FAN Li , XIAO Yi , LIU Shiyuan , ZHOU Xin . Assessment of Pulmonary Function Changes of AECOPD with Hyperpolarized 129Xe MR[J]. Chinese Journal of Magnetic Resonance, 2024 , 41(4) : 363 -372 . DOI: 10.11938/cjmr20243106

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