Chinese Journal of Magnetic Resonance >

2024 , Vol. 41 >Issue 4: 382 - 392

DOI: https://doi.org/10.11938/cjmr20243101

Articles

Design and Research of the dDNP Automated Dissolution System

  • ZENG Xiangzheng ,
  • CHEN Junfei ,
  • HUANG Chongyang ,
  • PI Haiya ,
  • CAO Li ,
  • HUANG Zhen ,
  • GUO Wenlong ,
  • FENG Jiwen ,
  • LIU Chaoyang
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  • 1. School of Electrical and Electronic Engineering, Wuhan Polytechnic University, Wuhan 430023, China
    2. State Key Laboratory of Magnetic Resonance and Atomic and Molecular Physics, Wuhan Center for Magnetic Resonance, Innovation Academy for Precision Measurement Science and Technology, Chinese Academy of Sciences, Wuhan 430071, China
    3. University of Chinese Academy of Sciences, Beijing 100049, China

Received date: 2024-03-18

  Online published: 2024-04-16

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Abstract

Dissolution dynamic nuclear polarization (dDNP) involves polarizing the sample under microwave irradiation at a low-temperature and strong-magnetic field, dissolving it by solvent of high-temperature and high-pressure, then injecting it rapidly into an NMR/MRI for detection. The dissolution system serves as a pivotal component in the dissolving and injecting process, with its performance directly affecting the melting and transfer efficiency and the high polarization retention. We present an automated dissolution system using a dual-loop proportional-integral-derivative (PID) control algorithm that can reach the target pressure of ~1.7 MPa after 9 min and control the internal pressure within 1.5%. The system can dissolve a solid sample of -271 ℃ in the self-developed 5 T dDNP polarizer and transfer it to the 7 T NMR system at a distance of 11.2 m for detection in 4 s, yielding a 9050-fold enhancement of 13C NMR signal of sodium [1-13C]-pyruvate at the solvated state. In summary, this work developed an automated dissolution system that simplifies the operation steps, ensures detection consistency, and improves experimental safety.

Key words： dissolution dynamic nuclear polarization; double-loop PID control algorithm; dissolution system; high temperature and high pressure

Cite this article

ZENG Xiangzheng , CHEN Junfei , HUANG Chongyang , PI Haiya , CAO Li , HUANG Zhen , GUO Wenlong , FENG Jiwen , LIU Chaoyang . Design and Research of the dDNP Automated Dissolution System[J]. Chinese Journal of Magnetic Resonance, 2024 , 41(4) : 382 -392 . DOI: 10.11938/cjmr20243101

References

[1] 裘祖文. 核磁共振波谱[M]. 北京: 科学出版社, 1989.
[2] ARDENKJAER-LARSEN J H, FRIDLUND B, GRAM A, et al. Increase in signal-to-noise ratio of > 10,000 times in liquid-state NMR[J]. Proc Natl Acad Sci, 2003, 100(18): 10158-10163.
[3] BOWEN S, HILTY C. Rapid sample injection for hyperpolarized NMR spectroscopy[J]. Phys Chem Chem Phys, 2010, 12(22): 5766-5770.
[4] DEY A, CHARRIER B, MARTINEAU E, et al. Hyperpolarized NMR metabolomics at natural 13C abundance[J]. Anal Chem, 2020, 92(22): 14867-14871.
[5] JANNIN S, COMMENT A, KURDZESAU F, et al. A 140GHz prepolarizer for dissolution dynamic nuclear polarization[J]. J Chem Phys, 2008, 128(24): 241102.
[6] COMMENT A, VAN DEN BRANDT B, UFFMANN K, et al. Design and performance of a DNP prepolarizer coupled to a rodent MRI scanner[J]. Concept Magn Reson B, 2007, 31(4): 255-269.
[7] CHENG T, CAPOZZI A, TAKADO Y, et al. Over 35% liquid-state 13C polarization obtained via dissolution dynamic nuclear polarization at 7 T and 1 K using ubiquitous nitroxyl radicals[J]. Phys Chem Chem Phys, 2013, 15(48): 20819-20822.
[8] BAUDIN M, VUICHOUD B, BORNET A, et al. A cryogen-consumption-free system for dynamic nuclear polarization at 9.4 T[J]. J Magn Reson, 2018, 294: 115-121.
[9] PINON A C, CAPOZZI A, ARDENKJAER-LARSEN J H. Hyperpolarization via dissolution dynamic nuclear polarization: new technological and methodological advances[J]. Magn Reson Mater Phy, 2021, 34: 5-23.
[10] BOWEN S, ARDENKJAER-LARSEN J H. Enhanced performance large volume dissolution-DNP[J]. J Magn Reson, 2014, 240: 90-94.
[11] ARDENKJAER-LARSEN J H. On the present and future of dissolution-DNP[J]. J Magn Reson, 2016, 264: 3-12.
[12] Lê T P, HYACINTHE J N, CAPOZZI A. How to improve the efficiency of a traditional dissolution dynamic nuclear polarization (dDNP) apparatus: Design and performance of a fluid path coMPatible dDNP/LOD-ESR probe[J]. J Magn Reson, 2022, 338: 107197.
[13] 张哲恺, 皮海亚, 冯继文, 等.5 T液体和溶融型DNP谱仪的研制[C]// 第二十一届全国波谱学学术年会论文摘要集, 2021.
[14] KIRYUTIN A S, RODIN B A, YURKOVSKAYA A V, et al. Transport of hyperpolarized samples in dissolution-DNP experiments[J]. Phys Chem Chem Phys, 2019, 21(25): 13696-13705.
[15] ELLIOTT S J, STERN Q, CEILLIER M, et al. Practical dissolution dynamic nuclear polarization[J]. Prog Nucl Magn Reson Spectrosc, 2021, 126: 59-100.
[16] 利格斯迈尔. 嵌入式系统软件工程-基础知识: 方法和应用[M]. 张聚, 译. 北京: 电子工业出版社, 2009.
[17] 乔治·埃利斯. 控制系统设计指南[M]. 汤晓君, 译. 北京: 机械工业出版社, 2016.
[18] YANG C, CHEN J F, CHEN L, et al. Design and implementation of NMR permanent magnet precision temperature controller[J]. Chinese J Magn Reson, 2018, 35(3): 294-302.
  杨畅, 陈俊飞, 陈黎, 等. NMR永磁体精密温度控制器的设计与实现[J]. 波谱学杂志, 2018, 35(3): 294-302.
[19] DONG T, LIANG S, WANG H, et al. Design and evaluation of a caloric stimulation device for fMRI studies[J]. Chinese J Magn Reson, 2016, 33(1): 54-65.
  董涛, 梁思, 王慧, 等. 一种用于fMRI的温度觉刺激装置的设计与验证[J]. 波谱学杂志, 2016, 33(1): 54-65.
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