Chinese Journal of Magnetic Resonance >
NMR Data Analysis of Acarbose
Received date: 2024-08-01
Online published: 2024-09-29
Acarbose, an α-glucosidase inhibitor, has been widely used in the treatment of type-II diabetes due to its unique mechanism of action. In this study, comprehensive and accurate 1H and 13C NMR data of acarbose in DMSO-d6, including 1H NMR data of all hydroxyl groups of acarbose as well as 1H and 13C NMR data of the dual signal of C-ring α and β, were reported for the first time. The assignment of 1H and 13C NMR data was conducted using DEPT-135, 1H-1H COSY, 1H-13C HSQC, and 1H-13C HMBC techniques. The molecular structure of acarbose was confirmed, providing a reliable data basis for the safety and quality control of acarbose drugs.
Key words： liquid-state NMR; structural assignment; 2D NMR; acarbose
LI Yujiang , ZHAO Wei , TAO Le , LU Bohua , ZHENG Guo , ZHANG Haiyan , GUO Xiaohe , ZHAO Tianzeng . NMR Data Analysis of Acarbose[J]. Chinese Journal of Magnetic Resonance, 2025 , 42(2) : 184 -194 . DOI: 10.11938/cjmr20243125
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