Chinese Journal of Magnetic Resonance >
MRI-traceable Nanoenzyme for Cascade Catalysis-enhanced Immunotherapy
Received date: 2025-03-14
Online published: 2025-05-06
The immunosuppressive tumor microenvironment (ITME) poses a significant challenge to anti-tumor immunotherapy. Our research develops a novel nanoenzyme based on Mn2+ and endogenous hemin. The nanozyme possesses superior multi-enzymatic activities, which could significantly reverse the ITME and trigger a vigorous anti-tumor immune response, thereby inhibiting both tumor growth and metastasis when used in conjunction with immune checkpoint inhibitor (ICI), αPD-L1. Moreover, it functions as a magnetic resonance imaging (MRI) contrast agent for the visualization of tumors and the trace of nanoenzyme.
SUI Meiju , ZHANG Lei , WANG Ruifang , LUO Yingying , LI Sha , QIU Maosong , XU Qiuyi , CHEN Daiqin , CHEN Shizhen , ZHOU Xin . MRI-traceable Nanoenzyme for Cascade Catalysis-enhanced Immunotherapy[J]. Chinese Journal of Magnetic Resonance, 2025 , 42(3) : 231 -248 . DOI: 10.11938/cjmr20253149
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