Chinese Journal of Magnetic Resonance >
Optimization of DW-MRS Acquisition Protocol: The Impact of Gating and Cycling Modes
Received date: 2025-04-02
Online published: 2025-05-12
Diffusion-weighted magnetic resonance spectroscopy (DW-MRS) measures metabolite apparent diffusion coefficients (ADC) to characterize cellular microstructures. However, physiological motion artifacts and low reproducibility limit its clinical application. This study investigates the effects of different gating methods and cycling modes on DW-MRS results. A total of 21 healthy subjects were included: 6 underwent DW-MRS scans under electrocardiogram (ECG) gating, respiratory gating, and no gating; the remaining 15 were scanned using internal and external b-value cycling to evaluate the impact of cycling modes on ADC reproducibility. Results showed that ECG gating reduced motion artifacts and mitigated ADC overestimation, while internal cycling improved reproducibility. The combination of ECG gating and internal cycling enhances ADC reliability, supporting the broader clinical application of DW-MRS.
WEN Yulin , LI Gaiying , WU Yupeng , LI Jianqi . Optimization of DW-MRS Acquisition Protocol: The Impact of Gating and Cycling Modes[J]. Chinese Journal of Magnetic Resonance, 2025 , 42(4) : 402 -413 . DOI: 10.11938/cjmr20253156
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