Physics guided multi-contrast magnetic resonance reconstruction diffusion model

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  • 1. School of Biomedical Engineering, Southern Medical University, Guangzhou 510515, China; 2. Research Center for Medical AI, Shenzhen 518055, China; 3. State Key Laboratory of Biomedical Imaging Science and System, Shenzhen Institute of Advanced Technology, Chinese Academy of Sciences, Shenzhen 518055, China; 4. Guangdong Provincial Key Laboratory of Multimodality Non-Invasive Brain-Computer Interfaces, Shenzhen Institute of Advanced Technology, Chinese Academy of Sciences, Shenzhen 518055, China

Received date: 2026-03-24

  Revised date: 2026-05-01

  Accepted date: 2026-05-26

  Online published: 2026-05-26

Abstract

Multi-contrast MRI allows for the simultaneous acquisition of multiple weighted images, enhancing imaging efficiency and providing rich quantitative information. However, reconstructing these images under high undersampling while ensuring anatomical consistency and physical plausibility remains a significant challenge. Existing methods often rely on scarce fully-sampled data or suffer from performance degradation due to domain shift. To address this, we propose a physics-prior-guided diffusion model that encodes MR signal evolution via Bloch equations into a dictionary-matching constraint. This constraint is directly coupled into the reverse sampling process, enabling physical correction of data-driven priors without retraining. Experimental results demonstrate superior generalization over supervised and self-supervised approaches, while the estimated parameter maps validate its high quantitative accuracy, highlighting its potential for clinical multi-contrast imaging.

Cite this article

SU Yilin, LIU Yuanyuan, CUI Zhuoxu, LIANG Dong . Physics guided multi-contrast magnetic resonance reconstruction diffusion model[J]. Chinese Journal of Magnetic Resonance, 0 : 0 . DOI: 10.11938/cjmr2026-3215

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