Chinese Journal of Magnetic Resonance >
Chiral Recognition of Ibuprofen Enatiomers by a Chiral Thiourea in the Presence of DMAP Using NMR
Received date: 2014-02-17
Revised date: 2014-10-29
Online published: 2014-12-05
The chiral recognition of racemic ibuprofen by thiourea was studied using 1H NMR spectroscopy. It was found that, with the participation of DMAP, excellent
recognition of the enantiomers of ibuprofen by thiourea could be achieved, and the process was not affected by the chiral bisthiourea and DMAP. To evaluate the ability of the chiral bisthiourea/DMAP for enantiomeric determination, several ee. values of ibuprofen samples were determined by 1H NMR, and the results coincided with the theoretical value.
Key words： NMR; DMAP; ibuprofen; chiral thiourea; enantiomeric purity
MA Min-shan , LEI Xin-xiang* . Chiral Recognition of Ibuprofen Enatiomers by a Chiral Thiourea in the Presence of DMAP Using NMR[J]. Chinese Journal of Magnetic Resonance, 2014 , 31(4) : 564 -571 . DOI: 10.11938/cjmr20140410
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