Chinese Journal of Magnetic Resonance >
An NMR Study of Phosphatidylcholine Small Unilamellar Vesicles
Received date: 2014-04-24
Revised date: 2014-10-28
Online published: 2014-12-05
Supported by
国家自然科学基金资助项目(21075132)，国家重点基础研究发展计划(“973 计划”)资助项目(2013CB910200).
Phosphatidylcholines (PC) is one of the most important phospholipids in the human and animal serum. It is the major constituent of lipoproteins that play important roles in the transport and metabolism of cholesterol. It was found that the many diseases, such as atherosclerosis, cancer, dementia and so on, were often associated with compositional and structural changes of phospholipids. Therefore, it is of interest to study the composition and structure of phospholipids. Here, small unilamellar vesicles (SUV) formed by PC were studied using 1D and 2D NMR experiments. It was found that there were two different [-N+(CH3)3] signals of PC, indicating that the SUV formed by PC may have a bilayer-spherical structure, not as previously thought to be a mono-layer structure.
Key words： NMR; bilayers; small unilamellar vesicles; phosphotidylcholine
LI Nan1 , 2 , SUN Peng1 , 2 , LIU Mai-li1 , ZHANG Xu1* . An NMR Study of Phosphatidylcholine Small Unilamellar Vesicles[J]. Chinese Journal of Magnetic Resonance, 2014 , 31(4) : 572 -578 . DOI: 10.11938/cjmr20140411
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